School of Pharmacy/State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, Guizhou, China; National Engineering Research Center of Miao's Medicines & Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education, Guiyang 550004, Guizhou, China; Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University, Guian New District, 550025, Guizhou, China.
School of Pharmacy/State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, Guizhou, China.
Eur J Med Chem. 2018 Feb 10;145:691-716. doi: 10.1016/j.ejmech.2018.01.011. Epub 2018 Jan 8.
Liver diseases are one of the leading causes of death in the world. In spite of tremendous advances in modern drug research, effective and safe hepatoprotective agents are still in urgent demand. Natural products are undoubtedly valuable sources for drug leads. A number of natural triterpenoids were reported to possess pronounced hepatoprotective effects, and triterpenoids have become one of the most important classes of natural products for hepatoprotective agents. However, the significance of natural triterpenoids has been underestimated in the hepatoprotective drug discovery, with only very limited triterpenoids being covered in the reviews of hepatoprotective natural products. In this paper, ca 350 natural triterpenoids with reported hepatoprotective effects in ca 120 references between 1975 and 2016 will be reviewed, and the structure-activity relationships of certain types of natural triterpenoids, if available, will be discussed. Patents are not included.
肝脏疾病是世界范围内主要的致死原因之一。尽管现代药物研究取得了巨大的进步，但仍迫切需要有效和安全的肝保护剂。天然产物无疑是药物先导的宝贵来源。有许多天然三萜类化合物被报道具有显著的肝保护作用，三萜类化合物已成为肝保护剂中最重要的天然产物之一。然而，在肝保护药物发现中，天然三萜类化合物的重要性被低估了，只有非常有限的三萜类化合物在肝保护天然产物的综述中被涉及。本文将综述 1975 年至 2016 年间的 120 篇参考文献中报道的具有肝保护作用的约 350 种天然三萜类化合物，并讨论某些类型的天然三萜类化合物的结构-活性关系（如果有的话）。专利未包括在内。
