State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P.R. China.
ChemMedChem. 2013 May;8(5):694-707. doi: 10.1002/cmdc.201200560. Epub 2013 Apr 8.
Autophagy is a highly conserved process in which damaged proteins and organelles are sequestered in double-membrane autophagosomes and delivered to lysosomes for degradation and recycling. As an efficient response to cellular stress, autophagy is essential for the maintenance of cellular homeostasis. Defective autophagy is associated with a variety of diseases, including cancer. This article summarizes current knowledge about the molecular mechanism of autophagy and its role in tumorigenesis. Particular focus is placed on the development of small-molecule regulators of autophagy and their potential application as anticancer therapeutic agents.
自噬是一种高度保守的过程，在此过程中，受损的蛋白质和细胞器被隔离在双层膜自噬体中，并递送至溶酶体进行降解和再循环。作为对细胞应激的有效反应，自噬对于维持细胞内稳态至关重要。自噬缺陷与多种疾病有关，包括癌症。本文总结了自噬的分子机制及其在肿瘤发生中的作用的最新知识。特别关注的是自噬小分子调节剂的开发及其作为抗癌治疗剂的潜在应用。
