Department of Otolaryngology-Head and Neck Surgery, Nara Medical University School of Medicine, Nara, Japan; and the.
Laryngoscope. 2013 Nov;123(11):2813-6. doi: 10.1002/lary.24099. Epub 2013 Apr 8.
OBJECTIVES/HYPOTHESIS: Benign paroxysmal positional vertigo (BPPV) frequently occurs in females over 50 years old, suggesting that a postmenopausal decrease in estrogen secretion might be involved in its onset. An estrogen deficiency is generally known to cause osteoporosis through a reduction in bone mass. This study was designed to investigate a clinical association between idiopathic BPPV and osteoporosis.
Case-control study.
We measured the bone mineral density (BMD) at the lumbar vertebrae in 61 patients with idiopathic BPPV who were postmenopausal women over 50 years old using dual-energy x-ray absorptiometry. After being treated with the canalith repositioning maneuver, the patients were followed up for at least 1 year.
Our results showed that the incidence of osteoporosis in patients with BPPV was 26.2%, which was similar to those observed in epidemiological surveys conducted in Japan. However, we found that in BPPV patients with osteoporosis, the incidence of recurrence was 56.3%, which was significantly higher than that observed in patients with normal bone mineral density (16.1%). Furthermore, the frequency of BPPV recurrence increased as BMD decreased.
These results suggest that osteoporosis is a risk factor for BPPV recurrence. The prognosis of BPPV might be clinically predicted by BMD reduction.
目的/假设：良性阵发性位置性眩晕（BPPV）常发生于 50 岁以上的女性，提示绝经后雌激素分泌减少可能与其发病有关。一般认为，雌激素缺乏会通过减少骨量导致骨质疏松症。本研究旨在探讨特发性 BPPV 与骨质疏松症之间的临床关联。
病例对照研究。
我们使用双能 X 射线吸收仪测量了 61 例特发性 BPPV 绝经后 50 岁以上女性患者的腰椎骨密度（BMD）。在进行管石复位手法治疗后，对患者进行了至少 1 年的随访。
我们的结果显示，BPPV 患者骨质疏松症的发生率为 26.2%，与日本进行的流行病学调查观察到的发生率相似。然而，我们发现，在骨质疏松症的 BPPV 患者中，复发率为 56.3%，明显高于骨密度正常的患者（16.1%）。此外，BPPV 复发的频率随着 BMD 的降低而增加。
这些结果表明，骨质疏松症是 BPPV 复发的一个危险因素。BMD 降低可能有助于临床预测 BPPV 的预后。
