Rao Yaojian, Zhu Wenxiao, Liu Huijuan, Jia Chunxia, Zhao Qingan, Wang Yongjun
Luoyang Orthopaedic-Traumatological Hospital, Luoyang, China.
J Int Med Res. 2013 Apr;41(2):473-81. doi: 10.1177/0300060513476426. Epub 2013 Feb 11.
To investigate the safety and therapeutic efficacy of autologous olfactory ensheathing cell (OEC) transplantation in cervical spinal cord injury (SCI).
Patients with cervical SCI of >6 months' duration were treated with autologous OECs, injected into the area surrounding the SCI under magnetic resonance imaging guidance, twice a week for 4 weeks. Patients were evaluated before treatment and at 3, 6, 12 and 24 months post-treatment, using the American Spinal Injury Association (ASIA) Impairment Scale, the ASIA sensory and motor score and the Functional Independence Measure (FIM) score.
Eight patients were recruited to the study. Three months after treatment, ASIA and FIM scores had improved significantly compared with pretreatment, though by 1 year no further significant improvements in the ASIA score were seen. The return of substantial sensation and motor activity in various muscles below the injury level was observed in three patients during follow-up. In addition, bladder function was restored in two patients. There were no serious complications postoperatively or during the follow-up period.
This study provides preliminary evidence of the safety and possible efficacy of autologous OEC transplantation.
探讨自体嗅鞘细胞（OEC）移植治疗颈脊髓损伤（SCI）的安全性和疗效。
对病程超过6个月的颈脊髓损伤患者，在磁共振成像引导下将自体嗅鞘细胞注入脊髓损伤部位周围，每周两次，共4周。在治疗前以及治疗后3、6、12和24个月，使用美国脊髓损伤协会（ASIA）损伤量表、ASIA感觉和运动评分以及功能独立性测量（FIM）评分对患者进行评估。
8名患者被纳入该研究。治疗3个月后，与治疗前相比，ASIA和FIM评分有显著改善，但到1年时，ASIA评分未见进一步显著改善。随访期间，3名患者损伤平面以下不同肌肉的大量感觉和运动活动恢复。此外，2名患者的膀胱功能恢复。术后及随访期间均无严重并发症。
本研究为自体嗅鞘细胞移植的安全性和可能的疗效提供了初步证据。
