Chen Di, Xi Haitao, Tan Ke, Huang Hongyun
Beijing Hongtianji Neuroscience Academy, Beijing 100143, China.
Department of Neurorehabilitation, Capital Medical University Affiliated Beijing Rehabilitation Hospital, Beijing 100144, China.
Case Rep Neurol Med. 2022 Jul 6;2022:9496652. doi: 10.1155/2022/9496652. eCollection 2022.
Spinal cord injury (SCI) is life-altering damage for patients, their family, and society. Transplantation of olfactory ensheathing cells has demonstrated neurorestoration effects for many neurological conditions, including SCI. But voiding and sex dysfunction in patients with chronic complete SCI is still a major issue even though neurorestorative therapies can restore their partial neurological functions. Here we report a case with traumatic complete SCI at the level of C6-C7 one year ago, who received OEC transplantation with intensive neurorehabilitation. The patient started to show clinical improvements within a few days after cell treatment. Six-year follow-up demonstrated his American Spinal Injury Association (ASIA)-Impairment Scale change from ASIA A to become ASIA C. The scores of International Association of Neurorestoratology Spinal Cord Injury Functional Rating Scale changed from 14 (prior to cell therapy) to 31 + 3 (six years after cell therapy). His main improvements in activity of daily life included eating, dressing and writing by himself, standing and walking, and urine control or voiding. His sex function recovered to be normal. He married and had a son through natural sex life. His improving functions and activities of daily life stayed stable in subsequent phone call follow-up. This was one individual case report. In the future, the deep mechanisms of why he got positive results, but other patients with similar condition did not get so much benefits from OEC transplantation should be explored.
脊髓损伤（SCI）对患者及其家庭和社会来说都是改变人生的损伤。嗅鞘细胞移植已在包括SCI在内的多种神经疾病中展现出神经修复作用。然而，尽管神经修复疗法能够恢复慢性完全性SCI患者的部分神经功能，但这些患者的排尿和性功能障碍仍是一个主要问题。在此，我们报告一例一年前在C6-C7水平发生创伤性完全性SCI的患者，其接受了嗅鞘细胞移植并辅以强化神经康复治疗。该患者在细胞治疗后的几天内开始出现临床改善。六年的随访显示，其美国脊髓损伤协会（ASIA）损伤分级从ASIA A级转变为ASIA C级。国际神经修复学会脊髓损伤功能评定量表的评分从细胞治疗前的14分变为细胞治疗六年后的31 + 3分。其日常生活活动能力的主要改善包括能够自行进食、穿衣和写字，能够站立和行走，以及能够控制排尿或自主排尿。其性功能恢复正常。他通过自然性生活结婚并育有一子。在随后的电话随访中，他改善的功能和日常生活活动能力保持稳定。这是一例个案报告。未来，应探究为何他取得了积极效果，而其他类似情况的患者却未从嗅鞘细胞移植中获得如此多益处的深层机制。
