Takami Toshihiro, Shimokawa Nobuyuki, Parthiban Jutty, Zileli Mehmet, Ali Sheena
Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Neurosurgery, Tsukazaki Hospital, Hyogo, Japan.
Neurospine. 2020 Dec;17(4):785-796. doi: 10.14245/ns.2040408.204. Epub 2020 Dec 31.
This is a review article examining the pharmacologic and regenerative cell therapy for spinal cord injury. A literature search during last 10 years were conducted using key words. Case reports, experimental (nonhuman) studies, papers other than English language were excluded. Up-to-date information on the pharmacologic and regenerative cell therapy for spinal cord injury was reviewed and statements were produced to reach a consensus in 2 separate consensus meeting of WFNS Spine Committee. The statements were voted and reached a consensus using Delphi method. Pharmacologic and regenerative cell therapy for spinal cord injury have long been an interest of many experimental and clinical researches. Clinical studies with methylpredinisolone have not shown clear cut benefit. Other drugs such as Rho inhibitor, minocycline, riluzole, granulocyte colony-stimulating factor have also been tried without significant benefits. Regenerative cell therapy using different types of stem cells, different inoculation techniques, and scaffolds have undergone many trials highlighting the efficacies of cells and their limitations. This review article summarizes the current knowledge on pharmacologic and regenerative cell therapy for spinal cord injury. Unfortunately, there is a need for further experimental and human trials to recommend effective pharmacologic and regenerative cell therapy.
这是一篇综述文章，探讨了脊髓损伤的药物治疗和再生细胞疗法。使用关键词对过去10年的文献进行了检索。排除了病例报告、实验性（非人类）研究以及非英文论文。在世界神经外科联合会（WFNS）脊柱委员会的两次独立共识会议上，对脊髓损伤的药物治疗和再生细胞疗法的最新信息进行了审查，并形成了声明以达成共识。这些声明采用德尔菲法进行投票并达成共识。脊髓损伤的药物治疗和再生细胞疗法长期以来一直是许多实验和临床研究的关注点。甲基强的松龙的临床研究并未显示出明确的益处。其他药物，如Rho抑制剂、米诺环素、利鲁唑、粒细胞集落刺激因子也已尝试使用，但均未取得显著效果。使用不同类型干细胞、不同接种技术和支架的再生细胞疗法已经历了许多试验，突出了细胞的疗效及其局限性。这篇综述文章总结了目前关于脊髓损伤的药物治疗和再生细胞疗法的知识。不幸的是，需要进一步的实验和人体试验来推荐有效的药物治疗和再生细胞疗法。
