Kotan Dilcan, Deniz Orhan, Aygul Recep, Yildirim Abdulkadir
Department of Neurology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
J Int Med Res. 2013 Apr;41(2):404-9. doi: 10.1177/0300060513477002. Epub 2013 Mar 7.
Orexins are hypothalamic neuropeptides that are involved in feeding, neuroendocrine regulation, sleep-wakefulness and sleep disorders (such as narcolepsy). This study investigated the relationship between serum and cerebrospinal fluid (CSF) orexin-A concentrations and infarct volume, in patients with ischaemic stroke.
Serum and CSF concentrations of orexin-A were determined 48-72 h after the onset of ischaemic stroke in patients, then compared with those of healthy control subjects of comparable age. Infarct volumes were measured using computerized tomography, 48-72 h after hospitalization.
Mean serum and CSF orexin-A concentrations were significantly lower among ischaemic stroke patients (n = 29) compared with control subjects (n = 13). There was a significant inverse correlation between infarct volumes and CSF orexin-A concentrations in patients with ischaemic stroke.
These data show that serum and CSF orexin-A concentrations decrease after cerebral ischaemia and may play a role in the development of brain injury. The orexin-A concentration in the CSF might be a useful biomarker for the assessment of progression of brain tissue damage during the early stages of ischaemic stroke.
食欲素是下丘脑神经肽，参与进食、神经内分泌调节、睡眠-觉醒及睡眠障碍（如发作性睡病）。本研究调查了缺血性脑卒中患者血清和脑脊液（CSF）中食欲素-A浓度与梗死体积之间的关系。
在患者缺血性脑卒中发病后48 - 72小时测定血清和CSF中食欲素-A的浓度，然后与年龄相仿的健康对照者进行比较。住院48 - 72小时后，使用计算机断层扫描测量梗死体积。
与对照者（n = 13）相比，缺血性脑卒中患者（n = 29）的血清和CSF中食欲素-A的平均浓度显著降低。缺血性脑卒中患者的梗死体积与CSF中食欲素-A浓度之间存在显著的负相关。
这些数据表明，脑缺血后血清和CSF中食欲素-A浓度降低，可能在脑损伤的发生发展中起作用。CSF中食欲素-A浓度可能是评估缺血性脑卒中早期脑组织损伤进展的有用生物标志物。
