Radji Maksum, Fauziah Siti, Aribinuko Nurgani
Laboratory of Microbiology and Biotechnology, Department of Pharmacy, Faculty of Mathematics and Science, University of Indonesia, Depok, 16424, Indonesia.
Asian Pac J Trop Biomed. 2011 Jan;1(1):39-42. doi: 10.1016/S2221-1691(11)60065-8.
To evaluate the sensitivity pattern of bacterial pathogens in the intensive care unit (ICU) of a tertiary care of Fatmawati Hospital Jakarta Indonesia.
A cross sectional retrospective study of bacterial pathogen was carried out on a total of 722 patients that were admitted to the ICU of Fatmawati Hospital Jakarta Indonesia during January 2009 to March 2010. All bacteria were identified by standard microbiologic methods, and their antibiotic susceptibility testing was performed using disk diffusion method.
Specimens were collected from 385 patients who were given antimicrobial treatment, of which 249 (64.68%) were cultured positive and 136 (35.32%) were negative. The most predominant isolate was Pseudomonas aeruginosa (P. aeruginosa) (26.5%) followed by Klebsiella pneumoniae (K. pneumoniae) (15.3%) and Staphylococcus epidermidis (14.9%). P. aeruginosa isolates showed high rate of resistance to cephalexin (95.3%), cefotaxime (64.1%), and ceftriaxone (60.9%). Amikacin was the most effective (84.4%) antibiotic against P. aeruginosa followed by imipenem (81.2%), and meropenem (75.0%). K. pneumoniae showed resistance to cephalexin (86.5%), ceftriaxone (75.7%), ceftazidime (73.0%), cefpirome (73.0%) and cefotaxime (67.9%), respectively.
Most bacteria isolated from ICU of Fatmawati Hospital Jakarta Indonesia were resistant to the third generation of cephalosporins, and quinolone antibiotics. Regular surveillance of antibiotic susceptibility patterns is very important for setting orders to guide the clinician in choosing empirical or directed therapy of infected patients.
评估印度尼西亚雅加达法玛瓦蒂医院三级护理重症监护病房（ICU）中细菌病原体的敏感性模式。
对2009年1月至2010年3月期间入住印度尼西亚雅加达法玛瓦蒂医院ICU的722例患者进行了细菌病原体的横断面回顾性研究。所有细菌均通过标准微生物学方法鉴定，并使用纸片扩散法进行抗生素敏感性测试。
从385例接受抗菌治疗的患者中采集标本，其中249例（64.68%）培养阳性，136例（35.32%）培养阴性。最主要的分离株是铜绿假单胞菌（26.5%），其次是肺炎克雷伯菌（15.3%）和表皮葡萄球菌（14.9%）。铜绿假单胞菌分离株对头孢氨苄（95.3%）、头孢噻肟（64.1%）和头孢曲松（60.9%）显示出高耐药率。阿米卡星是针对铜绿假单胞菌最有效的抗生素（84.4%），其次是亚胺培南（81.2%）和美罗培南（75.0%）。肺炎克雷伯菌分别对头孢氨苄（86.5%）、头孢曲松（75.7%）、头孢他啶（73.0%）、头孢匹罗（73.0%）和头孢噻肟（67.9%）耐药。
从印度尼西亚雅加达法玛瓦蒂医院ICU分离出的大多数细菌对第三代头孢菌素和喹诺酮类抗生素耐药。定期监测抗生素敏感性模式对于制定医嘱以指导临床医生选择感染患者的经验性或针对性治疗非常重要。
