柳叶红千层叶的生药学研究及抗炎活性
Pharmacognostic study and anti-inflammatory activity of Callistemon lanceolatus leaf.
作者信息
Kumar S, Kumar V, Prakash O M
机构信息
Institute of Pharmaceutical Sciences, Kurukshetra University, Haryana, India.
出版信息
Asian Pac J Trop Biomed. 2011 Jun;1(3):177-81. doi: 10.1016/S2221-1691(11)60022-1.
OBJECTIVE
To study detail pharmacognosy and anti-inflammatory activity of Callistemon lanceolatus (C. lanceolatus) leaf.
METHODS
Leaf sample was studied by organoleptic, macroscopical, microscopical, phytochemical and other WHO recommended methods for standardizations. The methanolic leaf extract of the plant was also screened for anti-inflammatory activity on carrageenan-induced paw edema in rat at doses of 200 and 400 mg/kg, orally. The detail pharmacognostic study of the C. lanceolatus leaf was carried out to lay down the standards which could be useful in future experimental studies.
RESULTS
C. lanceolatus methanolic leaf extract showed significant (P<0.05) anti-inflammatory activity at doses of 200 mg/kg and 400 mg/kg. This significant anti-inflammatory of C. lanceolatus methanolic leaf extract at the dose of 400 mg/kg was comparable with diclofenac sodium.
CONCLUSIONS
The pharmacognostic profile of the C. lanceolatus leaf is helpful in standardization for quality, purity and sample identification. The methanolic extract at a dose of 400 mg/kg shows a significant activity in comparison with the standard drug diclofenac sodium (50 mg/kg).
目的
研究柳叶红千层叶的详细生药学特征及抗炎活性。
方法
采用感官、宏观、微观、植物化学及世界卫生组织推荐的其他标准化方法对叶样本进行研究。还以200和400毫克/千克的剂量口服给予大鼠角叉菜胶诱导的爪肿胀模型，对该植物的甲醇叶提取物进行抗炎活性筛选。对柳叶红千层叶进行详细的生药学研究，以制定可用于未来实验研究的标准。
结果
柳叶红千层甲醇叶提取物在200毫克/千克和400毫克/千克剂量时显示出显著（P<0.05）的抗炎活性。柳叶红千层甲醇叶提取物在400毫克/千克剂量时的显著抗炎作用与双氯芬酸钠相当。
结论
柳叶红千层叶的生药学特征有助于质量、纯度和样品鉴定的标准化。与标准药物双氯芬酸钠（50毫克/千克）相比，400毫克/千克剂量的甲醇提取物显示出显著活性。
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