Osonuga O A, Osonuga A, Osonuga A A, Osonuga I O
Department of Pharmacology and Physiology, University of Cape Coast, Cape Coast, Ghana ; School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
Asian Pac J Trop Biomed. 2012 Jul;2(7):551-3. doi: 10.1016/S2221-1691(12)60095-1.
To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.
Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities. They were divided into two groups; 'Q' and 'A', receiving quinine and artemether, respectively. Jaundice was assessed by clinical examination.
Sixteen out of 32 children recruited (representing 50%) presented with jaundice on the day of recruitment. The mean age was (7.00°C2.56) years. On day 3, four patients in 'A' and six patients in 'Q' had jaundice. By day 7, no child had jaundice.
The study has shown that both drugs resolve jaundice although artemether relatively resolves it faster by the third day.
比较用奎宁和蒿甲醚治疗的重症疟疾患儿黄疸消退的模式。
从两家设有重症监护设施的医院招募了32名符合纳入标准的儿童进行该研究。他们被分为两组；“Q”组和“A”组，分别接受奎宁和蒿甲醚治疗。通过临床检查评估黄疸情况。
招募的32名儿童中有16名（占50%）在招募当天出现黄疸。平均年龄为（7.00±2.56）岁。在第3天，“A”组有4名患者、“Q”组有6名患者出现黄疸。到第7天，没有儿童有黄疸。
该研究表明两种药物都能使黄疸消退，尽管蒿甲醚在第3天相对消退得更快。
