蒿甲醚可使马拉维患脑型疟疾的儿童迅速苏醒。

Rapid coma resolution with artemether in Malawian children with cerebral malaria.

作者信息

Taylor T E, Wills B A, Kazembe P, Chisale M, Wirima J J, Ratsma E Y, Molyneux M E

机构信息

Queen Elizabeth Central Hospital, Blantyre, Malawi.

出版信息

Lancet. 1993 Mar 13;341(8846):661-2. doi: 10.1016/0140-6736(93)90423-e.

DOI:10.1016/0140-6736(93)90423-e

PMID:8095573

Abstract

Artemisinin compounds clear parasitaemia more rapidly than other drugs do in both mild and severe malaria, but no advantage in clinical efficacy has been shown. We have compared artemether treatment with standard quinine treatment in Malawian children with cerebral malaria. 65 unconscious children were randomly allocated to intravenous quinine (n = 37) or intramuscular artemether (n = 28) treatment. The two groups were well matched for various prognostic features. Median parasite clearance times were shorter in the artemether group (28 [interquartile range 18-34] vs 40 [36-44] h in the quinine group, p = 0.0002). Coma resolution times were also shorter with artemether than with quinine (8 [4-15] vs 14 [10-36] h, p = 0.01).

摘要

在轻度和重度疟疾中，青蒿素类化合物清除寄生虫血症的速度比其他药物更快，但尚未显示出在临床疗效方面的优势。我们比较了蒿甲醚治疗与标准奎宁治疗对马拉维患有脑型疟疾儿童的效果。65名昏迷儿童被随机分配接受静脉注射奎宁治疗（n = 37）或肌肉注射蒿甲醚治疗（n = 28）。两组在各种预后特征方面匹配良好。蒿甲醚组的中位寄生虫清除时间较短（28小时[四分位间距18 - 34小时]，而奎宁组为40小时[36 - 44小时]，p = 0.0002）。蒿甲醚治疗的昏迷缓解时间也比奎宁治疗的短（8小时[4 - 15小时]对14小时[10 - 36小时]，p = 0.01）。