蒿甲醚对健康未感染成年Wistar大鼠血液学参数的影响。
Effect of artemether on hematological parameters of healthy and uninfected adult Wistar rats.
作者信息
Osonuga I O, Osonuga O A, Osonuga A, Onadeko A A, Osonuga A A
机构信息
Department of Physiology, Olabisi Onabanjo University, Ikenne Remo, Nigeria.
出版信息
Asian Pac J Trop Biomed. 2012 Jun;2(6):493-5. doi: 10.1016/S2221-1691(12)60083-5.
OBJECTIVE
To evaluate the effect of short term artemether administration on some blood parameters in adult male Wistar rats.
METHODS
Sixty five albino rats with body weight of 190-220 g were used for the four-phased study. The animals were randomly divided into five groups. The first-four groups of 15 rats were further divided into 3 subgroups of 5 rats. The drug was administered orally at sub-optimal, therapeutic, and high doses of 25, 50 and 75 mg/kg bw, respectively to the rats for 1 day, 2 days and 3 days. Blood samples were collected by cardio-puncture from the rats for hematology at the end of each phase. The last group served as control, and they were given water ad libitum.
RESULTS
Artemether caused significant reduction (P<0.05) of the hematological profile of the animals in a dose dependent manner. Discontinuation of the drug use however showed gradual recovery of the depressed indices of the blood parameters.
CONCLUSIONS
The results suggest that artemether can induce reversible changes in hematological profiles of rats by extension man. This can probably aggravate anemia when artemether is administered to malaria patients. Hence, the study supports the use of the drug with caution especially in patients prone to anemic tendencies.
目的
评估短期给予蒿甲醚对成年雄性Wistar大鼠某些血液参数的影响。
方法
选用65只体重为190 - 220克的白化大鼠进行四阶段研究。将动物随机分为五组。前四组每组15只大鼠，再进一步分为3个亚组，每组5只。分别以25、50和75毫克/千克体重的次优剂量、治疗剂量和高剂量给大鼠口服药物，给药1天、2天和3天。在每个阶段结束时，通过心脏穿刺采集大鼠血液样本进行血液学检测。最后一组作为对照组，自由饮水。
结果
蒿甲醚以剂量依赖方式导致动物血液学指标显著降低（P<0.05）。然而，停止用药后，血液参数降低的指标逐渐恢复。
结论
结果表明，蒿甲醚可能会使大鼠血液学指标发生可逆性变化，进而可能影响人类。当给疟疾患者使用蒿甲醚时，这可能会加重贫血。因此，该研究支持谨慎使用该药物，尤其是对于有贫血倾向的患者。
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