顺铂诱导的人类肾毒性背后的科学：一项临床研究。
Science behind cisplatin-induced nephrotoxicity in humans: a clinical study.
作者信息
Arunkumar P A, Viswanatha G L, Radheshyam N, Mukund H, Belliyappa M S
机构信息
Department of Pharmacology, PES College of Pharmacy, Bangalore-560 050, India.
出版信息
Asian Pac J Trop Biomed. 2012 Aug;2(8):640-4. doi: 10.1016/S2221-1691(12)60112-9.
OBJECTIVE
To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity.
METHODS
We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes, creatinine, blood urea nitrogen (BUN) and urine potassium, sodium and pH levels before and after the cisplatin chemotherapy. All the patients had cancer and were treated with 40-50 mg/day cisplatin. Renal injury was assessed by measuring serum electrolytes, creatinine, BUN levels and urine potassium, sodium and pH levels.
RESULTS
The five cycles of cisplatin based chemotherapy resulted in hypomagnesia (P=0.029), hypocalcaemia (P=0.001*), hypophosphatemia (P=0.003*), hypokalemia (P=0.001*) and increased serum creatinine (P=0.001*) and BUN (P=0.292*) levels. In urine analysis, decrease in potassium (P=0.024*) was found, except potassium there was no significant changes in sodium and urine pH.
CONCLUSIONS
The present study demonstrates that, acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances, when no corrective measures were initiated.
目的
探讨血清电解质变化与顺铂所致肾毒性之间的关系。
方法
我们收集了18例接受顺铂化疗患者的数据，包括顺铂化疗前后的血清电解质、肌酐、血尿素氮（BUN）以及尿钾、钠和pH值水平。所有患者均患有癌症，接受40 - 50毫克/天顺铂治疗。通过测量血清电解质、肌酐、BUN水平以及尿钾、钠和pH值水平评估肾损伤。
结果
五个周期的顺铂化疗导致低镁血症（P = 0.029）、低钙血症（P = 0.001*）、低磷血症（P = 0.003*）、低钾血症（P = 0.001*），血清肌酐（P = 0.001*）和BUN（P = 0.292*）水平升高。尿液分析中，发现钾含量降低（P = 0.024*），除钾外，钠和尿pH值无显著变化。
结论
本研究表明，在未采取纠正措施的情况下，接受基于顺铂化疗的不同类型癌症患者中，由于电解质紊乱观察到急性肾毒性。
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