Tanideh Nader, Zarifi Fariba, Rafiee Shima, Khastkhodaei Maryam, Koohi Hosseinabadi Omid, Tarkesh Firoozeh, Kherad Zahra, Mojahed Taghi Maryam, Kamali Mahsa, Shekarkhar Golsa, Jahromi Mohamad, Zarifi Farzane
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran.
Galen Med J. 2018 Nov 29;7:e1258. doi: 10.22086/gmj.v0i0.1258. eCollection 2018.
Cisplatin is a cytotoxic agent in cancer therapy. Nephrotoxicity is considered as a side effect of cisplatin usage. Using rate models, we studied the possible protective impact of corn-silk (CS) extract against cisplatin-induced nephrotoxicity.
Thirty-five experimental rats were divided into five groups (n=7 per each group) as follow: C1: Control received distilled water only; C2: received one dose of cisplatin, and CS: received 300 mg/kg/day of CS. Both CS1 and CS2 received 200 and 300 mg/kg/day of the CS extract orally, individually, for eight consecutive days. CS1 and CS2 received a single dose of cisplatin on the first day only. The specific biochemical markers and histopathological alterations were evaluated.
According to our results, cisplatin administration could have induced severe degeneration in all parts of the nephron tubules and liver. Pre-treatment with CS exhibited a significant decrease in the malondialdehyde (MDA) levels as compared to the values obtained after treatment with cisplatin alone (P<0.01). Moreover, the CS extract with 200 mg dose showed significant (P<0.01) protection against the cisplatin-induced elevation of blood urea nitrogen. Further, the serum levels of alanine transaminase and aspartate transaminase were higher in the cisplatin-treated groups, when compared to the control group (P<0.05). Furthermore, the hepatic function was also improved in cisplatin-treated animals, which were pre-treated with CS.
CS has the potential to attenuate nephrotoxicity and lipid peroxidation induced by cisplatin in rats.
顺铂是癌症治疗中的一种细胞毒性药物。肾毒性被认为是使用顺铂的副作用。我们使用速率模型研究了玉米须（CS）提取物对顺铂诱导的肾毒性可能的保护作用。
将35只实验大鼠分为五组（每组n = 7），如下：C1：对照组仅接受蒸馏水；C2：接受一剂顺铂，CS组：接受300 mg/kg/天的CS。CS1和CS2分别连续八天每天口服200和300 mg/kg/天的CS提取物。CS1和CS2仅在第一天接受一剂顺铂。评估了特定的生化标志物和组织病理学改变。
根据我们的结果，顺铂给药可导致肾小管和肝脏各部位严重变性。与单独用顺铂治疗后获得的值相比，CS预处理使丙二醛（MDA）水平显著降低（P < 0.01）。此外，200 mg剂量的CS提取物对顺铂诱导的血尿素氮升高具有显著（P < 0.01）的保护作用。此外，与对照组相比，顺铂治疗组的血清谷丙转氨酶和谷草转氨酶水平更高（P < 0.05）。此外，用CS预处理的顺铂治疗动物的肝功能也得到改善。
CS有可能减轻顺铂诱导的大鼠肾毒性和脂质过氧化。
