• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Improved Chemotherapy Outcomes of Patients With Small-cell Lung Cancer Treated With Combined Alkalization Therapy and Intravenous Vitamin C.联合碱化疗法和静脉注射维生素C治疗小细胞肺癌患者的化疗效果改善
Cancer Diagn Progn. 2021 Jul 3;1(3):157-163. doi: 10.21873/cdp.10021. eCollection 2021 Jul-Aug.
2
Effects of Alkalization Therapy on Chemotherapy Outcomes in Advanced Pancreatic Cancer: A Retrospective Case-Control Study.碱化治疗对晚期胰腺癌化疗疗效的影响：一项回顾性病例对照研究。
In Vivo. 2020 Sep-Oct;34(5):2623-2629. doi: 10.21873/invivo.12080.
3
Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer.碱化治疗对转移性或复发性胰腺癌化疗结果的影响。
Anticancer Res. 2020 Feb;40(2):873-880. doi: 10.21873/anticanres.14020.
4
Effects of alkalization therapy on hepatocellular carcinoma: a retrospective study.碱化疗法对肝细胞癌的影响：一项回顾性研究。
Front Oncol. 2023 May 29;13:1179049. doi: 10.3389/fonc.2023.1179049. eCollection 2023.
5
Potential of Alkalization Therapy for the Management of Metastatic Pancreatic Cancer: A Retrospective Study.碱化疗法在转移性胰腺癌治疗中的潜力：一项回顾性研究
Cancers (Basel). 2023 Dec 21;16(1):61. doi: 10.3390/cancers16010061.
6
A prospective study on urine alkalization with an oral regimen consisting of sodium bicarbonate and acetazolamide in patients receiving high-dose methotrexate.一项关于在接受大剂量甲氨蝶呤治疗的患者中使用由碳酸氢钠和乙酰唑胺组成的口服方案进行尿液碱化的前瞻性研究。
Cancer Manag Res. 2019 Aug 30;11:8065-8072. doi: 10.2147/CMAR.S190084. eCollection 2019.
7
Tumor alkalization therapy: misconception or good therapeutics perspective? - the case of malignant ascites.肿瘤碱化疗法：误解还是良好的治疗前景？——以恶性腹水为例
Front Oncol. 2024 Feb 8;14:1342802. doi: 10.3389/fonc.2024.1342802. eCollection 2024.
8
Clinical review of alkalization therapy in cancer treatment.癌症治疗中碱化疗法的临床综述
Front Oncol. 2022 Sep 14;12:1003588. doi: 10.3389/fonc.2022.1003588. eCollection 2022.
9
Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE).预防性颅脑照射与舒尼替尼维持治疗对标准化疗后未经治疗的广泛期小细胞肺癌患者的积极相互作用：CALGB 30504（联盟）的二次分析
J Thorac Oncol. 2016 Mar;11(3):361-9. doi: 10.1016/j.jtho.2015.11.001. Epub 2015 Dec 24.
10
Survival and prognostic factors in elderly patients receiving second-line chemotherapy for relapsed small-cell lung cancer: Results from the Japanese Joint Committee of Lung Cancer Registry.老年复发性小细胞肺癌患者接受二线化疗的生存及预后因素：日本肺癌登记联合委员会的结果
Lung Cancer. 2020 Aug;146:160-164. doi: 10.1016/j.lungcan.2020.05.038. Epub 2020 Jun 6.

引用本文的文献

1
Immunotherapy of small cell lung cancer based on prognostic nutritional index.基于预后营养指数的小细胞肺癌免疫治疗
Front Immunol. 2025 May 26;16:1560241. doi: 10.3389/fimmu.2025.1560241. eCollection 2025.
2
Acid affairs in anti-tumour immunity.抗肿瘤免疫中的酸性事件
Cancer Cell Int. 2024 Oct 27;24(1):354. doi: 10.1186/s12935-024-03520-0.
3
How Does Cancer Occur? How Should It Be Treated? Treatment from the Perspective of Alkalization Therapy Based on Science-Based Medicine.癌症是如何发生的？应该如何治疗？基于循证医学的碱化疗法视角下的治疗。
Biomedicines. 2024 Sep 26;12(10):2197. doi: 10.3390/biomedicines12102197.
4
Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy.探索天然产物与碱化联合在癌症治疗中的潜在用途。
Pharmaceutics. 2024 Jun 10;16(6):787. doi: 10.3390/pharmaceutics16060787.
5
L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy.L-DOS47可提高胰腺癌肿瘤的pH值并增强对免疫疗法的反应。
Biomedicines. 2024 Feb 19;12(2):461. doi: 10.3390/biomedicines12020461.
6
Association between pH regulation of the tumor microenvironment and immunological state.肿瘤微环境的pH调节与免疫状态之间的关联。
Front Oncol. 2023 Jul 10;13:1175563. doi: 10.3389/fonc.2023.1175563. eCollection 2023.
7
Effects of alkalization therapy on hepatocellular carcinoma: a retrospective study.碱化疗法对肝细胞癌的影响：一项回顾性研究。
Front Oncol. 2023 May 29;13:1179049. doi: 10.3389/fonc.2023.1179049. eCollection 2023.
8
The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment.癌症与人体内部环境之间尚未充分探索的联系：对癌症预防和治疗的启示。
Front Oncol. 2022 Dec 22;12:1040034. doi: 10.3389/fonc.2022.1040034. eCollection 2022.
9
Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside.用三氧化二砷增强维生素 C 的氧化“特洛伊木马”作用，有效抑制 KRAS 突变型癌症：床边有希望的途径。
Cells. 2022 Nov 1;11(21):3454. doi: 10.3390/cells11213454.
10
Clinical review of alkalization therapy in cancer treatment.癌症治疗中碱化疗法的临床综述
Front Oncol. 2022 Sep 14;12:1003588. doi: 10.3389/fonc.2022.1003588. eCollection 2022.

本文引用的文献

1
Revisiting the Warburg effect: historical dogma versus current understanding.重新审视瓦堡效应：历史定论与当前认识。
J Physiol. 2021 Mar;599(6):1745-1757. doi: 10.1113/JP278810. Epub 2021 Jan 4.
2
Effects of Alkalization Therapy on Chemotherapy Outcomes in Advanced Pancreatic Cancer: A Retrospective Case-Control Study.碱化治疗对晚期胰腺癌化疗疗效的影响：一项回顾性病例对照研究。
In Vivo. 2020 Sep-Oct;34(5):2623-2629. doi: 10.21873/invivo.12080.
3
Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer.碱化治疗对转移性或复发性胰腺癌化疗结果的影响。
Anticancer Res. 2020 Feb;40(2):873-880. doi: 10.21873/anticanres.14020.
4
Acidosis and cancer: from mechanism to neutralization.酸中毒与癌症：从机制到中和。
Cancer Metastasis Rev. 2019 Jun;38(1-2):149-155. doi: 10.1007/s10555-019-09787-4.
5
Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer.药理剂量的抗坏血酸可降低胰腺癌放疗的正常组织毒性并增强肿瘤的放射敏感性。
Cancer Res. 2018 Dec 15;78(24):6838-6851. doi: 10.1158/0008-5472.CAN-18-1680. Epub 2018 Sep 25.
6
Intravenous Vitamin C for Cancer Therapy - Identifying the Current Gaps in Our Knowledge.静脉注射维生素C用于癌症治疗——识别我们现有知识中的差距
Front Physiol. 2018 Aug 23;9:1182. doi: 10.3389/fphys.2018.01182. eCollection 2018.
7
Assessments of tumor metabolism with CEST MRI.CEST MRI 评估肿瘤代谢。
NMR Biomed. 2019 Oct;32(10):e3943. doi: 10.1002/nbm.3943. Epub 2018 Jun 25.
8
High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study.大剂量静脉内给予抗坏血酸抑制胰腺癌生长和转移：机制和 I/IIa 期研究。
Sci Rep. 2017 Dec 7;7(1):17188. doi: 10.1038/s41598-017-17568-8.
9
Effects of an Alkaline Diet on EGFR-TKI Therapy in EGFR Mutation-positive NSCLC.碱性饮食对表皮生长因子受体酪氨酸激酶抑制剂治疗表皮生长因子受体突变阳性非小细胞肺癌的影响。
Anticancer Res. 2017 Sep;37(9):5141-5145. doi: 10.21873/anticanres.11934.
10
Reducing the Dietary Acid Load: How a More Alkaline Diet Benefits Patients With Chronic Kidney Disease.降低膳食酸负荷：更碱性的饮食如何使慢性肾病患者受益。
J Ren Nutr. 2017 May;27(3):151-160. doi: 10.1053/j.jrn.2016.11.006. Epub 2017 Jan 20.

联合碱化疗法和静脉注射维生素C治疗小细胞肺癌患者的化疗效果改善

Improved Chemotherapy Outcomes of Patients With Small-cell Lung Cancer Treated With Combined Alkalization Therapy and Intravenous Vitamin C.

作者信息

Hamaguchi Reo, Narui Ryoko, Morikawa Hiromasa, Wada Hiromi

机构信息

Japanese Society on Inflammation and Metabolism in Cancer, Kyoto, Japan.

出版信息

Cancer Diagn Progn. 2021 Jul 3;1(3):157-163. doi: 10.21873/cdp.10021. eCollection 2021 Jul-Aug.

DOI:10.21873/cdp.10021
PMID:35399313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8962782/
Abstract

BACKGROUND/AIM: This study aimed to investigate the effects of the combination of alkalization therapy (an alkaline diet and bicarbonate therapy) and intravenous vitamin C treatment on chemotherapy outcomes in patients with small-cell lung cancer (SCLC) (study registration: UMIN000043056).

PATIENTS AND METHODS

Twelve patients with SCLC in the intervention group (receiving both alkalization therapy and vitamin C treatment together with chemotherapy) were retrospectively compared to 15 patients with SCLC in the control group (receiving chemotherapy only).

RESULTS

The mean urine pH of the intervention group was significantly higher than that of the control group (7.32±0.45 vs. 6.44±0.74, respectively; p<0.005). The median overall survival for the intervention group was 44.2 months (95% confidence interval=22.0-not reached), as compared with 17.7 months for the control group (95% confidence intervaI=13.5-not reached; p<0.05).

CONCLUSION

The combination of alkalization therapy and intravenous vitamin C treatment may be associated with favorable outcomes in patients with SCLC receiving chemotherapy.

摘要

背景/目的：本研究旨在探讨碱化疗法（碱性饮食和碳酸氢盐疗法）与静脉注射维生素C联合治疗对小细胞肺癌（SCLC）患者化疗效果的影响（研究注册号：UMIN000043056）。

患者与方法

回顾性比较干预组12例SCLC患者（在接受化疗的同时接受碱化疗法和维生素C治疗）与对照组15例SCLC患者（仅接受化疗）。

结果

干预组的平均尿液pH值显著高于对照组（分别为7.32±0.45和6.44±0.74；p<0.005）。干预组的中位总生存期为44.2个月（95%置信区间=22.0-未达到），而对照组为17.7个月（95%置信区间=13.5-未达到；p<0.05）。

结论

碱化疗法与静脉注射维生素C联合治疗可能使接受化疗的SCLC患者获得较好的治疗效果。