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2011年某残疾人住宿机构甲型肝炎暴发的流行病学调查

Epidemiological investigation of an outbreak of hepatitis A at a residential facility for the disabled, 2011.

作者信息

Lim Hyun-Sul, Choi Kumbal, Lee Saerom

机构信息

Department of Preventive Medicine, Dongguk University College of Medicine, Gyeongju 780-714, Korea.

出版信息

J Prev Med Public Health. 2013 Mar;46(2):62-73. doi: 10.3961/jpmph.2013.46.2.62. Epub 2013 Mar 28.

DOI:10.3961/jpmph.2013.46.2.62
PMID:23573370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3615381/
Abstract

OBJECTIVES

An outbreak of hepatitis A occurred at a residential facility for the disabled in July 10, 2011. This investigation was carried out to develop a response plan, and to find the infection source of the disease.

METHODS

A field epidemiologist investigated the symptoms, vaccination histories, living environments, and probable infection sources with 51 residents and 31 teachers and staff members. In July 25, 81 subjects were tested for the hepatitis A virus antibody, and specimens of the initial 3 cases and the last case were genetically tested.

RESULTS

Three cases occurred July 10 to 14, twelve cases August 3 to 9, and the last case on August 29. Among the teachers and staff, no one was IgM positive (on July 25). The base sequences of the initial 3 and of the last case were identical. The vehicle of the outbreak was believed to be a single person. The initial 3 patients were exposed at the same time and they might have disseminated the infection among the patients who developed symptoms in early August, and the last patient might have, in turn, been infected by the early August cases.

CONCLUSIONS

The initial source of infection is not clear, but volunteers could freely come into contact with residents, and an infected volunteer might have been the common infection source of the initial patients. Volunteers' washing their hands only after their activity might be the cause of this outbreak. Although there may be other possible causes, it would be reasonable to ask volunteers to wash their hands both before and after their activities.

摘要

目的

2011年7月10日,一家残疾人寄宿机构爆发了甲型肝炎疫情。开展此次调查是为了制定应对计划并找出疾病的感染源。

方法

一名现场流行病学家调查了51名居民以及31名教师和工作人员的症状、疫苗接种史、生活环境和可能的感染源。7月25日,对81名受试者进行了甲型肝炎病毒抗体检测,并对最初3例和最后1例的样本进行了基因检测。

结果

3例病例发生在7月10日至14日,12例在8月3日至9日,最后1例在8月29日。在教师和工作人员中,无人IgM呈阳性(7月25日)。最初3例和最后1例的碱基序列相同。此次疫情的传播媒介被认为是同一个人。最初的3名患者同时暴露,他们可能在8月初出现症状的患者中传播了感染,而最后一名患者可能又被8月初的病例感染。

结论

最初的感染源尚不清楚,但志愿者可以自由接触居民,一名受感染的志愿者可能是最初患者的共同感染源。志愿者仅在活动后洗手可能是此次疫情爆发的原因。尽管可能还有其他原因,但要求志愿者在活动前后都洗手是合理的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb50/3615381/e4e5ff2f034c/jpmph-46-62-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb50/3615381/6bcc6a0edcea/jpmph-46-62-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb50/3615381/58fe19a2c475/jpmph-46-62-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb50/3615381/e4e5ff2f034c/jpmph-46-62-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb50/3615381/6bcc6a0edcea/jpmph-46-62-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb50/3615381/58fe19a2c475/jpmph-46-62-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb50/3615381/e4e5ff2f034c/jpmph-46-62-g003.jpg

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