Infectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Regional Centers for Disease Control and Prevention, Korea Disease Control and Prevention Agency, Seoul, Korea.
J Prev Med Public Health. 2021 Sep;54(5):370-375. doi: 10.3961/jpmph.21.349. Epub 2021 Sep 2.
The number of cases of hepatitis A virus (HAV) infections has sharply increased in Korea, especially among young adults. In this study, an HAV outbreak in a facility for disabled people was investigated, and we found epidemiological differences both between 2 different generations and between generally abled and disabled groups.
We analyzed the incubation period and attack rate of an HAV outbreak and investigated the prevalence of HAV antibodies among the staff and residents of a facility for the disabled. We performed a retrospective cohort study during the HAV outbreak, which lasted from February 8 to 25, 2019, including examinations of HAV antibody tests and post-exposure HAV vaccination for the staff or residents of the facility.
There were 9 confirmed cases in 2 staff members and 7 residents. Among 53 people (30 staff and 23 residents), except for the 9 confirmed cases and 1 staff member with a known history of HAV infection, HAV seroprevalence was seen in 16.7% of the staff under 40 years of age and 95.2% of those over 40 years of age, while the corresponding rates in the residents were 0.0% and 58.8%, respectively.
This result implies that it is necessary to prioritize HAV vaccination for vulnerable groups and workers of residential care facilities.
韩国甲型肝炎病毒(HAV)感染病例数量急剧增加,尤其是在年轻人中。本研究调查了一家残疾人设施中的 HAV 暴发情况,我们发现了 2 代人之间以及健全人群和残疾人群之间的流行病学差异。
我们分析了 HAV 暴发的潜伏期和发病率,并调查了残疾设施工作人员和居民中 HAV 抗体的流行情况。我们对 2019 年 2 月 8 日至 25 日期间的 HAV 暴发进行了回顾性队列研究,包括对设施工作人员或居民进行 HAV 抗体检测和暴露后 HAV 疫苗接种。
在 2 名工作人员和 7 名居民中发现了 9 例确诊病例。在 53 人(30 名工作人员和 23 名居民)中,除了 9 例确诊病例和 1 名已知有 HAV 感染史的工作人员外,40 岁以下工作人员的 HAV 血清阳性率为 16.7%,而 40 岁以上工作人员的 HAV 血清阳性率为 95.2%;居民中的相应比例分别为 0.0%和 58.8%。
这一结果表明,有必要优先为弱势群体和居住护理设施的工作人员接种 HAV 疫苗。