Toxicology Department and Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, Egypt.
CNS Neurol Disord Drug Targets. 2013 Aug;12(5):641-64. doi: 10.2174/18715273113129990071.
Coenzyme Q10 (CoQ10) is critical for the cell power supply in mitochondria. CoQ10 shuttles electrons from complexes I and II to complex III, and can be anti-oxdiative. Neurons require high energy for synaptic transmission and therefore the mitochondria dysfunction often leads to severe neuronal degeneration, as observed in many neurological disorders. CoQ10 supplementation has been widely used to treat aging, stroke, neuromuscular diseases, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, autosomal recessive cerebellar ataxias, Huntington's disease and amyotrophic lateral sclerosis. Here we discuss a large number of preclinical and clinical trials for CoQ10 to elucidate the mechanisms underlying CoQ10 therapy. The rational applications as a therapeutic agent in neurological disorders are discussed.
辅酶 Q10（CoQ10）对线粒体中的细胞供能至关重要。CoQ10 将电子从复合物 I 和 II 转移到复合物 III，并且具有抗氧化作用。神经元需要高能量进行突触传递，因此线粒体功能障碍常常导致严重的神经元退化，如许多神经退行性疾病中观察到的那样。CoQ10 补充剂已被广泛用于治疗衰老、中风、神经肌肉疾病、阿尔茨海默病、帕金森病、进行性核上性麻痹、常染色体隐性小脑共济失调、亨廷顿病和肌萎缩侧索硬化症。在这里，我们讨论了大量的 CoQ10 临床前和临床试验，以阐明 CoQ10 治疗的机制。讨论了将其作为治疗神经退行性疾病的治疗剂的合理应用。
