Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd., Mail Stop 2012, Kansas City, KS, 66160, USA,
Curr Treat Options Neurol. 2013 Jun;15(3):338-49. doi: 10.1007/s11940-013-0231-z.
Acute Inflammatory polyneuropathies are an important group of neuromuscular disorders and are referred to collectively as Guillain-Barré syndrome (GBS). Our knowledge regarding pathogenesis, diagnosis and management continues to expand, resulting in improved opportunities for identification and treatment. These autoimmune processes cause neuropathy by affecting various structures (myelin or axons), at different locations (nerve root, nerve cell bodies or peripheral nerve) with a variety of patterns. Most clinical neurologists will be involved in the management of patients with these disorders, and there are now a variety of reasonable therapies available for acquired demyelinating neuropathies. In this report, we review the distinctive clinical, laboratory and electro-diagnostic features that aid in their diagnosis, with emphasis on clinical characteristics that are of paramount importance in diagnosing specific conditions and determining the most appropriate therapies, and helpful in determining long-term prognosis.
急性炎症性多发性神经病是一组重要的神经肌肉疾病，通常被称为格林-巴利综合征（GBS）。我们对其发病机制、诊断和治疗的认识不断扩展，这为识别和治疗提供了更多的机会。这些自身免疫过程通过影响不同位置（神经根、神经细胞体或周围神经）的各种结构（髓鞘或轴突）导致神经病，其模式也多种多样。大多数临床神经科医生都会参与这些疾病患者的管理，现在有多种合理的治疗方法可用于治疗获得性脱髓鞘性神经病。在本报告中，我们回顾了有助于诊断的独特的临床、实验室和电诊断特征，重点介绍了对诊断特定疾病和确定最合适治疗方法至关重要的临床特征，并有助于确定长期预后。
