Bernstein H G, Kirschke H, Wiederanders B, Schmidt D, Rinne A
Institute of Anatomy, Medical Academy Magdeburg, GDR.
Brain Res Bull. 1990 Apr;24(4):543-9. doi: 10.1016/0361-9230(90)90157-u.
The lysosomal thiol proteinase, cathepsin B, has been localized in different regions of aged human brain by use of the peroxidase-antiperoxidase technique. Cathepsin B-immunoreactive material was detected in multiple neurons of human hippocampus, neocortical area A 10, prefrontal gyrus and nuc. basalis of Meynert as well as in single white matter astrocytes. In brains of Alzheimer disease-affected subjects cathepsin B was revealed in neuritic plaques too. Possible functional consequences with regard to normal aging, neuropeptide metabolism and pathological changes are discussed.
利用过氧化物酶-抗过氧化物酶技术，已将溶酶体硫醇蛋白酶组织蛋白酶B定位在老年人脑的不同区域。在人类海马体、新皮质A10区、前额叶回和迈内特基底核的多个神经元以及单个白质星形胶质细胞中检测到了组织蛋白酶B免疫反应性物质。在受阿尔茨海默病影响的大脑中，神经炎性斑块中也发现了组织蛋白酶B。讨论了其在正常衰老、神经肽代谢和病理变化方面可能的功能后果。
