Bernstein H G, Wiederanders B
Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, FRG.
Brain Res. 1994 Dec 26;667(2):287-90. doi: 10.1016/0006-8993(94)91509-1.
We studied the immunohistochemical localization of cathepsin E (cath E) in the brains of patients with Alzheimer disease (AD) and control brains. In the normal brain cathepsin E immunoreactivity was detectable in a small number (below 5%) of neocortical and hippocampal neurons. In AD brains cathepsin E antigen was revealed in most large cortical and hippocampal pyramids and in neurons of the Nuc. basalis of Meynert. Cathepsin E was also present in cerebral microvessels, microglia, and in senile plaques. The enzyme might play roles in the process of neurodegeneration taking place in AD.
我们研究了组织蛋白酶E（组织蛋白酶E）在阿尔茨海默病（AD）患者大脑及对照大脑中的免疫组化定位。在正常大脑中，少数（低于5%）新皮质和海马神经元可检测到组织蛋白酶E免疫反应性。在AD大脑中，组织蛋白酶E抗原在大多数大的皮质和海马锥体神经元以及Meynert基底核神经元中被发现。组织蛋白酶E也存在于脑微血管、小胶质细胞和老年斑中。该酶可能在AD发生的神经退行性变过程中发挥作用。
