Laboratório Nacional de Computação Científica, Av. Getúlio Vargas 333, Quitandinha, 25651-075 Petrópolis, Brazil.
Int J Numer Method Biomed Eng. 2013 May;29(5):601-14. doi: 10.1002/cnm.2547. Epub 2013 Apr 10.
In this work, a computational procedure is proposed to vascularize anatomical regions supplied by many inflow sites. The proposed methodology creates a partition of the territory to be vascularized into nonoverlapping subdomains that are independently supplied by the so-called perforator arteries (inflow sites). Then, in each subdomain, the constrained constructive optimization method is used to generate a network of vessels. The identification of subdomains in a certain vascular territory perfused by many perforator arteries turns out to be a fundamental problem towards understanding the morphological conformation of peripheral beds in the cardiovascular system. The methodology is assessed through two academic examples showing the main structural features of the so-defined vascular territory partition and the corresponding arterial networks. In addition, the vascularization of a three-dimensional sheet-like tissue is presented with potential application in flap planning and design.
在这项工作中，提出了一种计算程序来使由多个流入部位供应的解剖区域血管化。所提出的方法将待血管化的区域划分为非重叠的子域，这些子域由所谓的穿支动脉（流入部位）独立供应。然后，在每个子域中，使用约束构造优化方法来生成血管网络。在由许多穿支动脉灌注的特定血管区域中识别子域，对于理解心血管系统中周围床的形态结构至关重要。该方法通过两个学术示例进行评估，展示了所定义的血管区域划分和相应动脉网络的主要结构特征。此外，还提出了一种三维片状组织的血管化，可能在皮瓣规划和设计中有应用。
