Klein Thomas, André Raphael, Wieser Wolfgang, Pfeiffer Tom, Huber Robert
Lehrstuhl für BioMolekulare Optik, Fakultät für Physik, Ludwig-Maximilians-Universität München, Oettingenstr. 67, 80538 Munich, Germany.
Biomed Opt Express. 2013 Apr 1;4(4):619-34. doi: 10.1364/BOE.4.000619. Epub 2013 Mar 28.
Joint-aperture optical coherence tomography (JA-OCT) is an angle-resolved OCT method, in which illumination from an active channel is simultaneously probed by several passive channels. JA-OCT increases the collection efficiency and effective sensitivity of the OCT system without increasing the power on the sample. Additionally, JA-OCT provides angular scattering information about the sample in a single acquisition, so the OCT imaging speed is not reduced. Thus, JA-OCT is especially suitable for ultra high speed in-vivo imaging. JA-OCT is compared to other angle-resolved techniques, and the relation between joint aperture imaging, adaptive optics, coherent and incoherent compounding is discussed. We present angle-resolved imaging of the human retina at an axial scan rate of 1.68 MHz, and demonstrate the benefits of JA-OCT: Speckle reduction, signal increase and suppression of specular and parasitic reflections. Moreover, in the future JA-OCT may allow for the reconstruction of the full Doppler vector and tissue discrimination by analysis of the angular scattering dependence.
联合孔径光学相干断层扫描(JA - OCT)是一种角度分辨OCT方法,其中来自一个有源通道的照明光由多个无源通道同时探测。JA - OCT在不增加样品上功率的情况下提高了OCT系统的采集效率和有效灵敏度。此外,JA - OCT在单次采集时就能提供关于样品的角散射信息,因此不会降低OCT成像速度。所以,JA - OCT特别适用于超高速体内成像。将JA - OCT与其他角度分辨技术进行了比较,并讨论了联合孔径成像、自适应光学、相干和非相干复合之间的关系。我们以1.68 MHz的轴向扫描速率展示了人视网膜的角度分辨成像,并证明了JA - OCT的优势:减少散斑、增加信号以及抑制镜面反射和寄生反射。此外,未来JA - OCT可能通过分析角散射依赖性实现全多普勒矢量的重建和组织鉴别。