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用于眼科兆赫兹光学相干断层扫描中散斑减少和提高采集效率的联合孔径检测

Joint aperture detection for speckle reduction and increased collection efficiency in ophthalmic MHz OCT.

作者信息

Klein Thomas, André Raphael, Wieser Wolfgang, Pfeiffer Tom, Huber Robert

机构信息

Lehrstuhl für BioMolekulare Optik, Fakultät für Physik, Ludwig-Maximilians-Universität München, Oettingenstr. 67, 80538 Munich, Germany.

出版信息

Biomed Opt Express. 2013 Apr 1;4(4):619-34. doi: 10.1364/BOE.4.000619. Epub 2013 Mar 28.

Abstract

Joint-aperture optical coherence tomography (JA-OCT) is an angle-resolved OCT method, in which illumination from an active channel is simultaneously probed by several passive channels. JA-OCT increases the collection efficiency and effective sensitivity of the OCT system without increasing the power on the sample. Additionally, JA-OCT provides angular scattering information about the sample in a single acquisition, so the OCT imaging speed is not reduced. Thus, JA-OCT is especially suitable for ultra high speed in-vivo imaging. JA-OCT is compared to other angle-resolved techniques, and the relation between joint aperture imaging, adaptive optics, coherent and incoherent compounding is discussed. We present angle-resolved imaging of the human retina at an axial scan rate of 1.68 MHz, and demonstrate the benefits of JA-OCT: Speckle reduction, signal increase and suppression of specular and parasitic reflections. Moreover, in the future JA-OCT may allow for the reconstruction of the full Doppler vector and tissue discrimination by analysis of the angular scattering dependence.

摘要

联合孔径光学相干断层扫描(JA - OCT)是一种角度分辨OCT方法,其中来自一个有源通道的照明光由多个无源通道同时探测。JA - OCT在不增加样品上功率的情况下提高了OCT系统的采集效率和有效灵敏度。此外,JA - OCT在单次采集时就能提供关于样品的角散射信息,因此不会降低OCT成像速度。所以,JA - OCT特别适用于超高速体内成像。将JA - OCT与其他角度分辨技术进行了比较,并讨论了联合孔径成像、自适应光学、相干和非相干复合之间的关系。我们以1.68 MHz的轴向扫描速率展示了人视网膜的角度分辨成像,并证明了JA - OCT的优势:减少散斑、增加信号以及抑制镜面反射和寄生反射。此外,未来JA - OCT可能通过分析角散射依赖性实现全多普勒矢量的重建和组织鉴别。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ae6/3617723/a0d02257096e/boe-4-4-619-g001.jpg

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