Life Sciences, L'Ordal Advanced Research, 90 rue du Général Roguet, 92583 Clichy, France.
Altern Lab Anim. 2004 Jun;32 Suppl 1A:83-91. doi: 10.1177/026119290403201s13.
Models of reconstructed human skin provide useful tools for both basic research and evaluation of the safety and efficacy of dermato-cosmetological products. They can provide alternative models to replace human and animal experiments. However, their use requires confidence in their reproducibility and similarity of the results obtained as compared to in vivo experiments. Their morphology, architecture and properties must be as close as possible to human skin. The present paper reviews the results obtained on the EPISKIN model through characterisation of the model, reproducibility studies and multicentre studies or (pre)validations.
重建人体皮肤模型为基础研究和评估皮肤科化妆品产品的安全性和功效提供了有用的工具。它们可以提供替代模型来替代人体和动物实验。然而，它们的使用需要对其重现性和与体内实验获得的结果的相似性有信心。它们的形态、结构和性能必须尽可能接近人体皮肤。本文通过对 EPISKIN 模型的特征描述、重现性研究和多中心研究或（预）验证，综述了该模型的研究结果。
