Allergy and Immune Disorders, Murdoch Childrens Research Institute, Melbourne, Vic., Australia.
Pediatr Allergy Immunol. 2013 Jun;24(4):352-60. doi: 10.1111/pai.12075. Epub 2013 Apr 11.
The overall beneficial effects of breastfeeding for infants have been well documented, but its role in allergy prevention is controversial.
We investigated the relationship between breast milk immunomodulatory factors and subsequent development of eczema and atopic sensitization in the first year of life.
Day 7 and 28 breast milk samples were collected from mothers carrying infants at high risk of allergic disease. Aqueous-phase breast milk samples were assayed for TGF-β1, sCD14 and total IgA. Infants were assessed for the presence of eczema and atopic sensitization at 12 months of age. The levels of breast milk TGF-β1, sCD14 and total IgA were compared in infants who subsequently developed eczema and sensitization in the first year and those who did not.
The levels of breast milk sCD14, total IgA, and TGF-β1 at either day 7 or 28 were not associated with subsequent development of eczema or atopic sensitization during the first year of life.
Levels of breast milk immune parameters were not associated with eczema outcomes or sensitization in infants at 12 months. This suggests that apparent immunological effects on breast milk immunomodulatory factors may not necessarily lead to clinical benefits, and these immune markers may not be critical determinants of allergic disease in infancy.
母乳喂养对婴儿的整体有益影响已得到充分证实，但它在预防过敏方面的作用仍存在争议。
我们研究了母乳免疫调节因子与婴儿生命第一年中湿疹和特应性致敏的发展之间的关系。
从患有过敏疾病高风险婴儿的母亲身上采集第 7 天和第 28 天的母乳样本。检测水样母乳样本中的 TGF-β1、sCD14 和总 IgA。在 12 个月大时评估婴儿是否存在湿疹和特应性致敏。比较在婴儿生命的第一年中随后出现湿疹和致敏的婴儿与未出现的婴儿的母乳 TGF-β1、sCD14 和总 IgA 水平。
第 7 天或第 28 天的母乳 sCD14、总 IgA 和 TGF-β1 水平与生命第一年中随后出现的湿疹或特应性致敏无关。
在 12 个月大时，母乳免疫参数水平与婴儿湿疹结局或致敏无关。这表明母乳免疫调节因子的明显免疫作用不一定会带来临床益处，这些免疫标志物可能不是婴儿期过敏疾病的关键决定因素。
