Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Lett. 2013 Apr 19;15(8):1918-21. doi: 10.1021/ol400568u. Epub 2013 Apr 11.
Fe-catalyzed direct dehydrogenative C(3)-functionalization of tertiary arylamines was developed via activation of the sp(3) C(3)-H bond. The reaction is applicable to both cyclic and acyclic amines. The key process is the catalytic desaturative enamine formation from tertiary amines and position-selective C-C bond formation (addition to nitro olefins) at the β-carbon. Products can be converted to versatile and unique nitrogen-containing molecules.
铁催化的三级芳胺的直接脱氢 C(3)-官能化通过 sp(3) C(3)-H 键的活化来实现。该反应适用于环状和非环状胺。关键过程是从三级胺催化脱饱和烯胺形成和β-碳位置选择性 C-C 键形成（加成到硝基烯烃）。产物可以转化为多功能和独特的含氮分子。
