Vartiainen T, Lampelo S
National Public Health Institute, Department of Environmental Hygiene and Toxicology, Kuopio, Finland.
Environ Mol Mutagen. 1990;15(4):198-204. doi: 10.1002/em.2850150405.
The mutagenicity of chlorinated drinking waters processed from humus-rich surface waters has been shown to be very high. The effect of placental S9 on the mutagenicity of drinking waters has not been studied previously. The purpose of this study was to compare the effects of human placental and rat liver microsomal fractions on the mutagenicity of drinking waters processed from humus-rich surface waters. The samples of 34 drinking and two raw waters from 26 localities in Finland were tested for mutagenicity in Ames Salmonella typhimurium tester strain TA100 with and without metabolic activations. Between the drinking water samples, clear differences were recorded in the presence of placental and rat liver S9, suggesting different mutagens in the drinking waters. Rat liver S9 decreased the mutagenicities of drinking water concentrates, but placental S9 increased, decreased, or had no effect. It is not known if placental mutagenicity enhancing system might cause any health hazard to a developing fetus.
由富含有机质的地表水制备的氯化饮用水的致突变性已被证明非常高。胎盘S9对饮用水致突变性的影响此前尚未进行研究。本研究的目的是比较人胎盘和大鼠肝脏微粒体组分对由富含有机质的地表水制备的饮用水致突变性的影响。对来自芬兰26个地区的34份饮用水样本和2份原水样本，在有或无代谢激活的情况下，用鼠伤寒沙门氏菌测试菌株TA100检测其致突变性。在饮用水样本中，记录到在存在胎盘和大鼠肝脏S9的情况下有明显差异，表明饮用水中存在不同的诱变剂。大鼠肝脏S9降低了饮用水浓缩物的致突变性，但胎盘S9则增加、降低或无影响。尚不清楚胎盘致突变性增强系统是否可能对发育中的胎儿造成任何健康危害。
