Agha-Hosseini Farzaneh, Mirzaii-Dizgah Iraj
Department of Oral Medicine, Dental Research Center, Dentistry School, Tehran University of Medical Sciences, Tehran, Iran.
J Contemp Dent Pract. 2013 Jan 1;14(1):1-3. doi: 10.5005/jp-journals-10024-1259.
Unstimulated whole salivary p53 was assessed in patients suffering from erosive and plaque-like form of oral lichen planus (OLP).
Eighteen patients with erosive form, 17 patients suffering from plaque-like form and 38 noninvolvement subjects were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA.
The mean concentration of salivary p53 was significantly higher in patients with plaque-like form compared to both patients with erosive form and the control group.
We conclude that plaque like form of OLP is important in view of the potential for malignancy and is not safety form.
It seems that all forms of OLP must be considered accurately, should be followed up with biannual examinations, and if possible, assessment of salivary p53 every year.
评估糜烂型和斑块状口腔扁平苔藓（OLP）患者的非刺激性全唾液p53水平。
纳入18例糜烂型患者、17例斑块状患者和38例对照者。采用酶联免疫吸附测定法（ELISA）检测非刺激性全唾液p53水平。
与糜烂型患者和对照组相比，斑块状患者唾液p53平均浓度显著更高。
我们得出结论，鉴于斑块状OLP有恶变可能，其并非安全类型，具有重要意义。
似乎所有类型的OLP都必须得到准确评估，应每半年进行一次检查随访，并且如果可能的话，每年对唾液p53进行评估。
