SG Austria, 20 Biopolis Way #05-518 Centros, Singapore, Singapore.
Int J Cancer. 2013 Oct 1;133(7):1530-5. doi: 10.1002/ijc.28210. Epub 2013 May 15.
There remains great controversy as to whether mouse mammary tumor virus (MMTV), the etiological agent of mammary cancer in mice, or a closely related human retrovirus, plays a role in the development of breast cancer in humans. On one hand, retroviruses such as human T-cell lymphotropic virus and human immunodeficiency virus (HIV) are known causative agents of cancer (in the case of HIV, albeit, indirectly), but attempts to associate other retroviruses with human cancers have been difficult. A recent, high profile, example has been the postulated involvement of another mouse virus, xenotropic murine leukemia virus-related virus, in human prostate cancer, which is now thought to be due to contamination. Here, we review some of the more recent evidence for and against the involvement of MMTV in human breast cancer and suggest future studies that may allow a definitive answer to this conundrum.
关于是否是鼠乳腺肿瘤病毒（MMTV），即引发小鼠乳腺癌的病原体，还是一种密切相关的人类逆转录病毒，在人类乳腺癌的发展中发挥了作用，目前仍存在很大争议。一方面，某些逆转录病毒，如人类 T 细胞嗜淋巴细胞病毒和人类免疫缺陷病毒（HIV），已被确认为癌症的致病因子（HIV 是间接致病因子），但将其他逆转录病毒与人类癌症联系起来的尝试一直很困难。最近一个备受瞩目的例子是，假定另一种小鼠病毒，即多瘤病毒相关的嗜鼠白血病病毒，与人类前列腺癌有关，但现在认为这是由于污染所致。在这里，我们回顾了一些最近关于 MMTV 是否参与人类乳腺癌的更多证据，并提出了一些未来的研究，这些研究可能会为这个难题提供一个明确的答案。
