Hesch R D, Harms H, Rittinghaus E F, Brabant G
Abteilung für klinische Endokrinologie, Departement Innere Medizin der Medizinischen Hochschule Hannover.
Fortschr Med. 1990 Apr 15;108(11):219-21.
A paradigma of osteoporosis pathology is discussed, at the center of which is the hormone-related disturbance of the osteoblast/osteoclast functional unit. A liberal replacement of estrogen-gestagen in post-menopausal women is advocated. Early diagnosis with the aid of quantitative computed tomography makes it possible to establish the indication for timely hormonal treatment in the future, which can result in a measureable increase in bone mass. Late therapy, that is, treatment initiated after the occurrence of fractures, has proven largely ineffective.
本文讨论了骨质疏松症病理学的一个范例，其核心是成骨细胞/破骨细胞功能单位与激素相关的紊乱。提倡对绝经后妇女进行雌激素 - 孕激素的充分替代治疗。借助定量计算机断层扫描进行早期诊断，使得未来能够确定及时进行激素治疗的适应症，这可能会使骨量有可测量的增加。而晚期治疗，即在骨折发生后开始的治疗，已被证明在很大程度上是无效的。
