纤维状淀粉样蛋白与临床前认知衰退相关。
Fibrillar amyloid correlates of preclinical cognitive decline.
机构信息
Department of Psychiatry & Psychology, Mayo Clinic in Arizona, Scottsdale, AZ, USA.
Banner Alzheimer's Institute, Phoenix, AZ, USA.
出版信息
Alzheimers Dement. 2014 Jan;10(1):e1-8. doi: 10.1016/j.jalz.2013.01.009. Epub 2013 Apr 11.
Abstract
BACKGROUND
It is not known whether preclinical cognitive decline is associated with fibrillar β-amyloid (Aβ) deposition irrespective of apolipoprotein E (APOE) ε4 status.
METHODS
From a prospective observational study of 623 cognitively normal individuals, we identified all subjects who showed preclinical decline of at least 2 standard deviations beyond the decline of the entire group in memory or executive function. Fourteen decliners were matched by APOE ε4 gene dose, age, sex, and education with 14 nondecliners. Dynamic Pittsburgh compound B (PiB) positron emission tomography (PET) scans, the Logan method, statistical parametric mapping, and automatically labeled regions of interest were used to characterize and compare cerebral-to-cerebellar PiB distribution volume ratios (DVRs), reflecting fibrillar Aβ burden.
RESULTS
At P < .005 (uncorrected), decliners had significantly greater DVRs in comparison to nondecliners.
CONCLUSIONS
Asymptomatic longitudinal neuropsychological decline is associated with subsequent increased fibrillar amyloid deposition, even when controlling for APOE ε4 genotype.
摘要
背景
目前尚不清楚临床前认知能力下降是否与纤维状β-淀粉样蛋白（Aβ）沉积有关，而不论载脂蛋白 E（APOE）ε4 状态如何。
方法
我们从一项对 623 名认知正常个体的前瞻性观察性研究中，确定了所有在记忆或执行功能方面的认知下降至少超过整个组下降 2 个标准差的临床前下降的受试者。按照 APOE ε4 基因剂量、年龄、性别和教育程度，对 14 名下降者与 14 名未下降者进行了匹配。使用动态匹兹堡化合物 B（PiB）正电子发射断层扫描（PET）扫描、Logan 法、统计参数映射和自动标记感兴趣区域来描述和比较反映纤维状 Aβ负担的大脑与小脑 PiB 分布体积比（DVR）。
结果
在未校正的情况下，下降者的 DVR 明显大于未下降者（P <.005）。
结论
即使在控制 APOE ε4 基因型的情况下，无症状的纵向神经心理学下降也与随后的纤维状淀粉样蛋白沉积增加有关。
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