II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Institut für Molekulare Immunologie, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Gastroenterology. 2013 Jul;145(1):63-78. doi: 10.1053/j.gastro.2013.03.052. Epub 2013 Apr 10.
Over the past decade, the microenvironment of gastrointestinal tumors has gained increasing attention because it is required for tumor initiation, progression, and metastasis. The tumor microenvironment has many components and has been recognized as one of the major hallmarks of epithelial cancers. Although therapeutic strategies for gastrointestinal cancer have previously focused on the epithelial cell compartment, there is increasing interest in reagents that alter the microenvironment, based on reported interactions among gastrointestinal epithelial, stromal, and immune cells during gastrointestinal carcinogenesis. We review the different cellular components of the gastrointestinal tumor microenvironment and their functions in carcinogenesis and discuss how improving our understanding of the complex stromal network could lead to new therapeutic strategies.
在过去的十年中，胃肠道肿瘤的微环境越来越受到关注，因为它是肿瘤发生、进展和转移所必需的。肿瘤微环境有许多组成部分，已被认为是上皮癌的主要特征之一。尽管胃肠道癌的治疗策略以前集中在上皮细胞区室，但基于胃肠道上皮细胞、基质和免疫细胞在胃肠道癌变过程中的相互作用的报道，人们对改变微环境的试剂越来越感兴趣。我们回顾了胃肠道肿瘤微环境的不同细胞成分及其在癌变中的功能，并讨论了如何加深对复杂基质网络的理解可能导致新的治疗策略。
