Nakagomi K, Takeuchi M, Tanaka H, Tomizuka N, Nakajima T
Fermentation Research Institute, Agency of Industrial Science and Technology, Ibaraki, Japan.
J Antibiot (Tokyo). 1990 May;43(5):462-9. doi: 10.7164/antibiotics.43.462.
Microorganisms producing anti-inflammatory substances were screened by the inhibitory effect on mast cell degranulation. Three new compounds related to pentaene macrolide eurocidins, eurocidins C, D and E, have been isolated from the culture broth of Streptoverticillium eurocidicum IFO 13491 as the inhibitors. Their molecular weights and molecular formulae were estimated as 781.89 and C39H59NO15 for eurocidin C, 795.92 and C40H61NO15 for eurocidin D, and 779.92 and C40H61NO14 for eurocidin E, respectively.
通过对肥大细胞脱粒的抑制作用筛选出产生抗炎物质的微生物。从杀欧洲菌素链霉菌IFO 13491的培养液中分离出三种与戊二烯大环内酯类杀欧洲菌素相关的新化合物，即杀欧洲菌素C、D和E作为抑制剂。它们的分子量和分子式分别估计为：杀欧洲菌素C为781.89和C₃₉H₅₉NO₁₅，杀欧洲菌素D为795.92和C₄₀H₆₁NO₁₅，杀欧洲菌素E为779.92和C₄₀H₆₁NO₁₄。
