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贻贝启发的表面修饰和形貌线索对成肌细胞行为的协同作用。

Combined effect of mussel-inspired surface modification and topographical cues on the behavior of skeletal myoblasts.

机构信息

Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 305-701, Republic of Korea.

出版信息

Adv Healthc Mater. 2013 Nov;2(11):1445-50. doi: 10.1002/adhm.201300067. Epub 2013 Apr 15.

DOI:10.1002/adhm.201300067
PMID:23584891
Abstract

The combined effect of mussel-inspired polydopamine (PDA) surface functionalization and topographical cues on the behavior of skeletal myoblasts is described. On PDA-modified nanofibers, myogenic protein expression and the fusion of myoblasts are increased significantly compared with those on unmodified nanofibers. The multinucleate myotubes on the aligned nanofibers are oriented in a direction parallel to the nanofibers.

摘要

本文描述了贻贝启发的聚多巴胺（PDA）表面功能化和形貌线索对成肌细胞行为的协同影响。与未修饰的纳米纤维相比，PDA 修饰的纳米纤维上的成肌蛋白表达和肌细胞融合显著增加。在取向纳米纤维上，多核肌管沿纳米纤维平行方向排列。

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