Tea Muy-Kheng M, Fan Lei, Delancey James W, Staudigl Christine, Steurer Stefan, Lang Christina, Shao Zhi-Ming, Singer Christian F
Department of Breast Surgery, Shanghai Cancer Institute, Fudan University, Shanghai, China.
Tumour Biol. 2013 Aug;34(4):2379-82. doi: 10.1007/s13277-013-0786-z. Epub 2013 Apr 13.
Ethnic differences in breast cancer are well described in studies comparing Hispanic and African-American populations to Caucasian populations. The aim of this study was to analyze the biological characteristics of breast cancer (BC) in the young Asian/Han Chinese population compared to Caucasians/Central Europeans. Histopathologies of 642 invasive BC in women at the age of 40 years and younger were analyzed in China and Austria. Pearson's chi-squared test was used to assess differences in the analyzed populations. Significantly larger BC >2 cm (p < 0.0001) and poorly differentiated BC (p = 0.02) as well as more triple-negative BC (p = 0.002) were identified among the Han Chinese group compared to the Central European group. This analysis will provide ethnic-specific insight into the biological characteristics of BC in young patients worldwide.
在比较西班牙裔、非裔美国人群体与白种人群体的研究中，乳腺癌的种族差异已有详尽描述。本研究旨在分析年轻亚洲/汉族人群与高加索人/中欧人群相比，乳腺癌（BC）的生物学特征。在中国和奥地利，对642例40岁及以下女性浸润性乳腺癌的组织病理学进行了分析。采用Pearson卡方检验评估分析人群之间的差异。与中欧人群相比，汉族人群中显著更大的BC>2 cm（p<0.0001）、低分化BC（p = 0.02）以及更多的三阴性BC（p = 0.002）被识别出来。该分析将为全球年轻患者乳腺癌的生物学特征提供种族特异性见解。
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