Gao Ji-dong, Wang Jing, Feng Xiao-li, Zhong Yu-xin, Wang Xiang
Breast Cancer Center, Department of Abdominal Surgical Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhonghua Zhong Liu Za Zhi. 2009 Sep;31(9):683-6.
To analyze the characteristics of hormone receptor status in Chinese females with breast cancer.
The clinicopathological data of 5758 female breast cancer patients surgically treated in our breast cancer center from Jan. 1997 to Oct. 2008 were retrospectively analyzed.
The positive rates of estrogen receptor (ER) and progesterone receptor (PR) were 64.1% and 70.2%, respectively. The ER positive rate was significantly higher in elderly, post-menopausal females with a smaller tumor and well-differentiated histology (P < 0.05), while the PR positive rate was significantly correlated with only histological differentiation and tumor size (P < 0.05). The ER and PR positive rates were significantly higher in the patients with lymph node metastasis than that in those without (P < 0.05). Multivariate analysis showed that the histological differentiation, T stage, N stage and menopause status were significantly correlated with ER positive rate, while histological differentiation, T stage and N stage were significantly correlated with PR positive rate.
Our results show that the ER positive rate of breast cancer in Chinese women is lower than that in western high incidence areas. The ER positive rate is significantly correlated with age, histological differentiation, tumor size, and menopause status. The PR positive rate is correlated only with histological differentiation and tumor size. Interestingly, the ER and PR positive rates are significantly higher in the patients with axillary lymph node metastases than that in those without. However, further study is needed to verify this special phenomenon.
分析中国女性乳腺癌患者激素受体状态的特征。
回顾性分析1997年1月至2008年10月在我院乳腺癌中心接受手术治疗的5758例女性乳腺癌患者的临床病理资料。
雌激素受体（ER）和孕激素受体（PR）的阳性率分别为64.1%和70.2%。ER阳性率在年龄较大、绝经后、肿瘤较小且组织学分级高分化的女性中显著更高（P<0.05），而PR阳性率仅与组织学分级和肿瘤大小显著相关（P<0.05）。有淋巴结转移患者的ER和PR阳性率显著高于无淋巴结转移者（P<0.05）。多因素分析显示，组织学分级、T分期、N分期和绝经状态与ER阳性率显著相关，而组织学分级、T分期和N分期与PR阳性率显著相关。
我们的结果表明，中国女性乳腺癌的ER阳性率低于西方高发病地区。ER阳性率与年龄、组织学分级、肿瘤大小和绝经状态显著相关。PR阳性率仅与组织学分级和肿瘤大小相关。有趣的是，有腋窝淋巴结转移患者的ER和PR阳性率显著高于无腋窝淋巴结转移者。然而，需要进一步研究来证实这一特殊现象。
