Park Na-Jin, Kang Duck-Hee
School of Nursing, University of Pittsburgh in Pennsylvania.
Oncol Nurs Forum. 2013 Sep;40(5):490-500. doi: 10.1188/13.ONF.40-05AP.
PURPOSE/OBJECTIVES: To examine racial differences in inflammatory cytokine levels (interleukin [IL]-6 and interferon-gamma [IFN-γ]) and breast cancer (BC) risk factors between healthy Caucasian and African American women; to examine differences in relationships of inflammatory cytokine levels with BC risk factors between these groups of women; and to determine the independent contribution of race to IL-6 and IFN-γ after controlling for relevant covariates.
Cross-sectional and correlational descriptive design.
Community surrounding a state university health system in the southeastern United States.
113 healthy women (65 Caucasians and 48 African Americans) aged 20 years or older and not pregnant.
Secondary analysis of data collected from self-report questionnaires and blood samples.
Inflammatory cytokine levels, BC risk factors (age, age at menarche, age at first live birth, family history of BC, breast biopsy, breastfeeding history and duration, body mass index, and physical activity), and race.
Significant racial differences were noted in IL-6 and IFN-γ levels, reproductive or hormonal and lifestyle BC risk factors, and relationships between African American and Caucasian women. Controlling for all other effects, race appeared to be a significant predictor for IL-6 and IFN-γ.
Racial differences in inflammatory cytokines and BC risk factors may provide partial evidence for existing racial disparities in BC for African American and Caucasian women. Additional studies are needed to confirm that potential.
Additional biobehavioral research in racial disparities in BC may help to inform nurses to target race-specific modifications of lifestyle and behavioral factors to reduce BC health disparity between African American and Caucasian women.
Being an African American woman predicted a higher level of inflammatory cytokine production after controlling for selected BC risk factors. Great potential exists for inflammatory responses as one of the underlying biologic mechanisms for existing BC disparity and for culturally tailored lifestyle or behavioral modification interventions for reducing BC risk and racial disparity.
目的/目标：研究健康的白种人和非裔美国女性在炎性细胞因子水平（白细胞介素[IL]-6和干扰素-γ[IFN-γ]）及乳腺癌（BC）风险因素方面的种族差异；研究这些女性群体中炎性细胞因子水平与BC风险因素之间关系的差异；并在控制相关协变量后确定种族对IL-6和IFN-γ的独立影响。
横断面和相关性描述性设计。
美国东南部一所州立大学健康系统周边的社区。
113名年龄在20岁及以上且未怀孕的健康女性（65名白种人和48名非裔美国人）。
对通过自我报告问卷和血液样本收集的数据进行二次分析。
炎性细胞因子水平、BC风险因素（年龄、初潮年龄、首次生育年龄、BC家族史、乳腺活检、母乳喂养史及持续时间、体重指数和身体活动）以及种族。
在IL-6和IFN-γ水平、生殖或激素及生活方式BC风险因素以及非裔美国女性和白种女性之间的关系方面发现了显著的种族差异。在控制所有其他影响因素后，种族似乎是IL-6和IFN-γ的显著预测因素。
炎性细胞因子和BC风险因素的种族差异可能为非裔美国女性和白种女性在BC方面现有的种族差异提供部分证据。需要进一步研究来证实这一可能性。
关于BC种族差异的更多生物行为研究可能有助于告知护士针对特定种族调整生活方式和行为因素，以减少非裔美国女性和白种女性之间的BC健康差异。
在控制选定的BC风险因素后，非裔美国女性被预测会产生更高水平的炎性细胞因子。作为现有BC差异的潜在生物学机制之一，炎性反应以及针对文化定制的生活方式或行为改变干预措施在降低BC风险和种族差异方面具有巨大潜力。
