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致命性疟疾：Marchiafava 和 Bignami 是对的。

Lethal malaria: Marchiafava and Bignami were right.

机构信息

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

J Infect Dis. 2013 Jul 15;208(2):192-8. doi: 10.1093/infdis/jit116. Epub 2013 Apr 12.

DOI:10.1093/infdis/jit116
PMID:23585685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3685223/
Abstract

One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.

摘要

120 年前，意大利疟疾学家马奇亚法瓦和比尼亚米提出，致死性恶性疟原虫疟疾的基本病理过程是微血管阻塞。从那时起，又提出了几种替代假说。这些假说构成了辅助干预的基础，但要么无效，要么有害。最近的证据强烈表明，马奇亚法瓦和比尼亚米是正确的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/5fbfaa077a69/jit11606.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/2bb5c761311c/jit11601.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/8863e0cad6fa/jit11602.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/e5f9dc03767d/jit11603.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/62edf6a7d068/jit11604.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/879da60bec8b/jit11605.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/5fbfaa077a69/jit11606.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/2bb5c761311c/jit11601.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/8863e0cad6fa/jit11602.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/e5f9dc03767d/jit11603.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/62edf6a7d068/jit11604.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/879da60bec8b/jit11605.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6eb6/3685223/5fbfaa077a69/jit11606.jpg

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