Greeley S, Johnson W T, Schafer D, Johnson P E
Department of Food and Nutrition, North Dakota State University, Fargo.
J Am Coll Nutr. 1990 Jun;9(3):265-71. doi: 10.1080/07315724.1990.10720379.
An animal study was conducted to examine the effects of alcohol consumption on placental transfer of zinc during late gestation. Throughout pregnancy, rat dams were fed a nutritionally adequate diet with 30% of total kcal as alcohol. On days 18 and 21 of pregnancy, zinc-65 was injected subcutaneously into the dams and the dams were killed 24 hours later; tissues were removed for analyses. Maternal serum, liver, kidney, and heart zinc decreased with gestational age while total fetal zinc increased. Neither the decrease in maternal organ zinc nor fetal accretion were affected by alcohol consumption. Placental zinc concentration also declined with developmental age and was not influenced by alcohol consumption. The decrease in placental zinc was accompanied by a decrease in zinc associated with 4-10-kD proteins of placental cytosol. Our results suggest that zinc flux during late rat gestation is a well-regulated process that is not influenced by alcohol consumption. Coordination of the transfer apparently is influenced by maternal blood concentration of zinc, placental zinc-binding proteins, and fetal demand for zinc.
进行了一项动物研究，以检查孕期晚期酒精摄入对锌的胎盘转运的影响。在整个孕期，给大鼠母鼠喂食营养充足的饮食，其中30%的总热量来自酒精。在妊娠第18天和第21天，将锌-65皮下注射到母鼠体内，24小时后将母鼠处死；取出组织进行分析。母鼠血清、肝脏、肾脏和心脏中的锌随着胎龄的增加而减少，而胎儿体内锌的总量增加。母鼠器官锌含量的减少和胎儿锌的增加均不受酒精摄入的影响。胎盘锌浓度也随着发育年龄的增加而下降，且不受酒精摄入的影响。胎盘锌的减少伴随着胎盘细胞质中与4-10-kD蛋白质结合的锌的减少。我们的结果表明，大鼠孕期晚期的锌通量是一个调节良好的过程，不受酒精摄入的影响。锌转运的协调显然受母鼠血液锌浓度、胎盘锌结合蛋白和胎儿对锌的需求的影响。
