Department of Neuropathology, Institute of Pathology, University Hospital Basel, Basel, Switzerland.
Brain Pathol. 2013 May;23(3):342-9. doi: 10.1111/bpa.12044.
The soluble microtubule-associated protein tau forms hyperphosphorylated, insoluble and filamentous inclusions in a number of neurodegenerative diseases referred to as "tauopathies." In Alzheimer's disease, tau pathology develops in a stereotypical manner, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. Propagation of tau pathology is also a characteristic of argyrophilic grain disease, where the tau lesions spread throughout the limbic system. Significantly, isoform composition and morphology of tau filaments can differ between tauopathies, suggesting the existence of distinct tau strains. Extensive experimental findings indicate that prion-like mechanisms underly the pathogenesis of tauopathies.
可溶性微管相关蛋白 tau 在许多被称为“tau 病”的神经退行性疾病中形成过度磷酸化、不溶性和丝状包涵体。在阿尔茨海默病中，tau 病理学以一种刻板的方式发展，最初的病变出现在蓝斑和内嗅皮层，从那里似乎扩散到海马体和新皮层。tau 病理学的传播也是嗜银颗粒病的一个特征，tau 病变在边缘系统中广泛传播。重要的是，tau 病之间 tau 丝的亚型组成和形态可以不同，表明存在不同的 tau 株。广泛的实验结果表明，朊病毒样机制是 tau 病发病机制的基础。
