Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673.
BMC Biol. 2013 Apr 15;11:37. doi: 10.1186/1741-7007-11-37.
First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.
该通路最初在果蝇中被发现，可调控广泛的发育过程，与多种癌症相关。2002 年发表的该通路化学调节剂筛选的成功，为将基础发育生物学研究成果转化为治疗应用开辟了新的篇章。小分子通路激动剂现在被用于对干细胞进行编程，而拮抗剂则被证明是有效的抗癌疗法。
