Drug Discovery for Tropical Diseases, Suite 230, San Diego, CA 92121, USA.
Bioorg Med Chem Lett. 2013 May 15;23(10):2829-43. doi: 10.1016/j.bmcl.2013.03.067. Epub 2013 Mar 27.
This digest covers some of the most relevant progress in malaria drug discovery published between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such drugs can target the blood stage of the disease to alleviate the symptoms, the liver stage to prevent relapses, and the transmission stage to protect other humans. The pipeline for the blood stage is becoming robust, but this should not be a source of complacency, as the current therapies set a high standard. Drug discovery efforts directed towards the liver and transmission stages are in their infancy but are receiving increasing attention as targeting these stages could be instrumental in eradicating malaria.
本文摘涵盖了 2010 年至 2012 年间发表的疟疾药物发现领域最相关的进展。开发新的抗疟药物迫在眉睫。这些药物可以针对疾病的血液阶段以缓解症状，针对肝脏阶段以预防复发，针对传播阶段以保护其他人。血液阶段的研发管道正在变得强大，但这不应成为自满的理由，因为目前的疗法设定了高标准。针对肝脏和传播阶段的药物发现工作尚处于起步阶段，但越来越受到关注，因为针对这些阶段可能是消除疟疾的关键。
