Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia.
Arch Bronconeumol. 2013 Aug;49(8):326-9. doi: 10.1016/j.arbres.2013.01.014. Epub 2013 Apr 12.
Recently, multi-ethnic reference ranges for spirometry have been created for use worldwide. In comparison, forced oscillation technique (FOT) reference values are limited to specific equipment and study populations, with current FOT reference ranges created in a Caucasian population. We aimed to develop FOT reference ranges for preschool-aged Mexican children and to compare these with current FOT reference ranges.
Respiratory resistance (Rrs) and reactance (Xrs) was measured in healthy Mexican children three to five years of age using commercial FOT equipment. The relationship between height and Rrs and Xrs was determined using regression analyses, taking into account age, weight, sex, and exposure to tobacco smoke. Reference equations were calculated for the Mexican children and Z-scores determined for Rrs and Xrs at 6 and 8Hz. A paired t-test assessed the difference in Z-scores between the Australian reference values and those created for the Mexican cohort.
FOT was successfully measured in 584 children. Height was a significant predictor of Rrs and Xrs at 6 and 8Hz (P<.05). Z-scores calculated using the Australian reference equations overestimated lung function in Mexican children for both Rrs and Xrs at 6 and 8Hz (P<.001).
The development of FOT reference ranges specific to Mexican preschool-aged children will allow for the correct interpretation of FOT measurements. This study also showed that current FOT reference ranges overestimate lung function in Mexican children. Highlighting, the importance of using ethnic appropriate reference ranges for interpreting lung function.
最近，已经为全球范围内的使用创建了多民族参考范围的肺活量测定法。相比之下，强迫震荡技术（FOT）参考值仅限于特定的设备和研究人群，而当前的 FOT 参考值是在白种人群中创建的。我们旨在为学龄前墨西哥儿童制定 FOT 参考值，并将其与当前的 FOT 参考值进行比较。
使用商用 FOT 设备测量了 3 至 5 岁健康墨西哥儿童的呼吸阻力（Rrs）和电抗（Xrs）。使用回归分析确定身高与 Rrs 和 Xrs 之间的关系，同时考虑年龄、体重、性别和暴露于烟草烟雾的情况。为墨西哥儿童计算参考方程式，并确定 6Hz 和 8Hz 时 Rrs 和 Xrs 的 Z 分数。配对 t 检验评估了澳大利亚参考值与为墨西哥队列创建的参考值之间 Z 分数的差异。
FOT 成功测量了 584 名儿童。身高是 6Hz 和 8Hz 时 Rrs 和 Xrs 的重要预测因子（P<.05）。使用澳大利亚参考方程式计算的 Z 分数高估了墨西哥儿童的肺功能，无论是在 Rrs 还是 Xrs 上，在 6Hz 和 8Hz 时均如此（P<.001）。
为学龄前墨西哥儿童制定特定的 FOT 参考值范围将允许正确解释 FOT 测量值。本研究还表明，当前的 FOT 参考值高估了墨西哥儿童的肺功能。这凸显了使用适合特定种族的参考值来解释肺功能的重要性。
