Ribeiro Fernando Carlos Vetromille, Lopes Agnaldo José, Melo Pedro Lopes de
Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering and BioVasc Research Laboratory, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Pulmonary Function Laboratory, Pedro Ernesto University Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Clin Respir J. 2018 Jun;12(6):2126-2135. doi: 10.1111/crj.12783. Epub 2018 Mar 24.
The forced oscillation technique (FOT) is a particularly useful test of the mechanical properties of the respiratory system that has an increasingly important role in lung function laboratories. There is general agreement in the literature that the determination of reference values is of utmost importance in the clinical use of the FOT.
Our aim was to present reference values for whole-breath FOT measurements, establish which anthropometric variables were more predictive of impedance parameters, and provide all the details to adequately adopt these reference equations in individual laboratories.
We prospectively evaluated a randomly selected non-smoking sample of the adult Brazilian population (288 subjects, 144 males and 144 females aged 20-86 years). The volunteers were separated by sex and divided into six groups based on decade of age. Sex-specific linear prediction equations were developed by multiple regression analysis using age, body mass and height as explanatory variables.
Age introduced a slight, but significant, reduction of resistance in men (P < .001) and women (P < .001). In general, significantly higher values of resistance were observed in females (P < .0001). Among the anthropometric variables analyzed, height was the best predictor for all parameters studied.
This study provides an original frame of reference for the FOT in Brazilian males and females aged 20-86 years. Height was the best predictor of respiratory impedance parameters. Details contributing to an adequate adoption of these reference equations elsewhere by transference and verification are also provided.
强迫振荡技术（FOT）是一种对呼吸系统力学特性特别有用的测试方法，在肺功能实验室中发挥着越来越重要的作用。文献中普遍认为，参考值的确定在FOT的临床应用中至关重要。
我们的目的是给出全呼吸FOT测量的参考值，确定哪些人体测量变量对阻抗参数的预测性更强，并提供在各个实验室中充分采用这些参考方程的所有详细信息。
我们前瞻性地评估了随机抽取的巴西成年非吸烟人群样本（288名受试者，144名男性和144名女性，年龄在20 - 86岁之间）。志愿者按性别分开，并根据年龄的十年分组为六组。使用年龄、体重和身高作为解释变量，通过多元回归分析建立了性别特异性线性预测方程。
年龄使男性（P <.001）和女性（P <.001）的阻力略有但显著降低。总体而言，女性的阻力值明显更高（P <.0001）。在所分析的人体测量变量中，身高是所有研究参数的最佳预测指标。
本研究为20 - 86岁的巴西男性和女性提供了FOT的原始参考框架。身高是呼吸阻抗参数的最佳预测指标。还提供了通过转移和验证在其他地方充分采用这些参考方程的详细信息。
