Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
J Am Chem Soc. 2013 Jun 19;135(24):8770-3. doi: 10.1021/ja400636d. Epub 2013 Apr 19.
Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.
自从干细胞成为新一代药物以来,人们越来越努力地通过血管内注射将干细胞递送到靶组织。然而,治疗用干细胞缺乏检测和黏附靶组织的能力。因此,本研究提出了一种生物活性超支化聚甘油(HPG)的合成方法,该方法可以非侵入性地与干细胞结合,并进一步引导它们到达靶位,如炎症内皮。整个过程类似于白细胞被动员到受损的内皮的方式。