Rahman M U, Ahmed S, Schumacher H R, Zeiger A R
University of Pennsylvania School of Medicine, Philadelphia.
J Rheumatol. 1990 May;17(5):621-5.
Bacterial cell wall peptidoglycan, the arthritogenic factor in adjuvant induced arthritis, may also be involved in the etiology of some human rheumatic diseases. Patients with some seronegative rheumatic diseases like ankylosing spondylitis and Reiter's syndrome have elevated antibody titers to peptidoglycan. Using an ELISA with soluble peptidoglycan, we examined the sera of 110 patients with psoriatic arthritis, psoriasis without arthritis and a variety of other joint diseases. Antibody titers were significantly higher (p less than 0.001) among the 22 patients with psoriatic arthritis than the 16 patients with psoriasis without arthritis. Patients with other seronegative arthritides also had higher levels of antipeptidoglycan antibodies than patients with rheumatoid (seropositive) arthritis, osteoarthritis and crystal induced arthritis. Our results furnish additional support for the suggestion for a bacterial role in the pathogenesis of psoriatic and some other seronegative arthritides.
细菌细胞壁肽聚糖是佐剂诱导性关节炎中的致关节炎因子，也可能参与某些人类风湿性疾病的病因。一些血清阴性风湿性疾病患者，如强直性脊柱炎和赖特综合征患者，其针对肽聚糖的抗体滴度升高。我们使用可溶性肽聚糖酶联免疫吸附测定法（ELISA）检测了110例银屑病关节炎患者、无关节炎的银屑病患者以及多种其他关节疾病患者的血清。22例银屑病关节炎患者的抗体滴度显著高于16例无关节炎的银屑病患者（p小于0.001）。与类风湿性（血清阳性）关节炎、骨关节炎和晶体诱导性关节炎患者相比，其他血清阴性关节炎患者的抗肽聚糖抗体水平也更高。我们的结果为细菌在银屑病和其他一些血清阴性关节炎发病机制中起作用的观点提供了更多支持。
