Department of Biology, Washington University in St. Louis, St. Louis, MO, USA.
Channels (Austin). 2013 May-Jun;7(3):215-20. doi: 10.4161/chan.24505. Epub 2013 Apr 16.
The bacterial mechanosensitive channel MscS provides an excellent model system for the study of mechanosensitivity and for investigations into the cellular response to hypoosmotic shock. Numerous studies have elucidated the structure, function and gating mechanism of Escherichia coli MscS, providing a wealth of information for the comparative analysis of MscS family members in bacteria, archaea, fungi and plants. We recently reported the electrophysiological characterization of MscS-Like (MSL)10, a MscS homolog from the model flowering plant Arabidopsis thaliana. Here we summarize our results and briefly compare MSL10 to previously described members of the MscS family. Finally, we comment on how this and other recently published studies illuminate the possible mechanisms by which ion selectivity is accomplished in this fascinating family of channels.
细菌机械敏感通道 MscS 为机械敏感性研究和细胞对低渗冲击反应的研究提供了一个极好的模型系统。许多研究阐明了大肠杆菌 MscS 的结构、功能和门控机制，为比较细菌、古菌、真菌和植物中 MscS 家族成员提供了丰富的信息。我们最近报道了 MscS 样（MSL）10 的电生理学特性，MSL10 是来自模式开花植物拟南芥的 MscS 同源物。在这里，我们总结了我们的结果，并简要比较了 MSL10 与之前描述的 MscS 家族成员。最后，我们评论了这些和其他最近发表的研究如何阐明在这个迷人的通道家族中实现离子选择性的可能机制。
