Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK.
Prenat Diagn. 2013 Sep;33(9):823-30. doi: 10.1002/pd.4129. Epub 2013 Jun 3.
The aim of this case-control study at 30-33 weeks, a few days or weeks before the clinical onset of preeclampsia (PE), was to assess whether serum concentrations of cytokines differ between patients who are destined to develop PE and those with uncomplicated pregnancies.
A panel of cytokines was measured using Luminex technology at 30-33 weeks' gestation in 39 cases that developed PE at or after 34 weeks and 117 unaffected controls.
The serum concentrations of most analysed cytokines were no different in women who developed PE than in controls. The proportions of women with detectable concentrations of MIP-1α and IL-8 were significantly lower in those with PE than in the controls (MIP-1α: 14/39 vs 76/117, P = 0.003; IL-8:13/39 vs 83/117, P < 0.0001). The median maternal serum concentration of IL-1β was significantly lower in the PE cases than in the controls (0.38 pg/mL, range 0.01-0.92, vs 0.60 pg/mL, range 0.02-3.54, P = 0.005).
Our findings do not lend support to the hypothesis that systemic inflammation precedes the onset of PE or that cytokines are good markers for such inflammation and certainly the panel of cytokines we examined does not provide useful prediction of subsequent development of PE.
本病例对照研究在子痫前期（PE）临床发病前几天或几周（30-33 周）进行，旨在评估在发展为 PE 的患者与无并发症妊娠患者之间，血清细胞因子浓度是否存在差异。
在 34 周及以后发生 PE 的 39 例病例和 117 例未受影响的对照者妊娠 30-33 周时，采用 Luminex 技术检测细胞因子谱。
与对照组相比，发生 PE 的女性血清中大多数分析细胞因子的浓度无差异。PE 组中可检测到 MIP-1α 和 IL-8 浓度的女性比例明显低于对照组（MIP-1α：14/39 比 76/117，P=0.003；IL-8：13/39 比 83/117，P<0.0001）。PE 病例的母血清 IL-1β 中位数明显低于对照组（0.38pg/mL，范围 0.01-0.92，比 0.60pg/mL，范围 0.02-3.54，P=0.005）。
我们的研究结果不支持全身炎症先于 PE 发病的假说，也不支持细胞因子是此类炎症的良好标志物的假说，而且我们研究的细胞因子谱并不能提供对随后发生 PE 的有用预测。
