钯催化的 2-碘苯胺与迈克尔受体二乙氧基羰基丁烯二酸酯的分子间环羰基化反应。
Palladium-catalyzed intermolecular cyclocarbonylation of 2-iodoanilines with the Michael acceptor, diethyl ethoxycarbonylbutendienoate.
机构信息
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, K1N 6N5, Canada.
出版信息
J Org Chem. 2012 May 4;77(9):4420-4. doi: 10.1021/jo300173g. Epub 2012 Apr 26.
PMID:22480192
Abstract
Palladium-catalyzed intermolecular cyclocarbonylation of 2-iodoanilines with diethyl ethoxycarbonylbutendienoate produces 2,3,3-triethoxycarbonyl-2,3-dihydro-4(1H)-quinolinone derivatives in moderate to good yields. This protocol involves Michael addition and subsequent carbonylation.
摘要
钯催化 2-碘苯胺与二乙氧基羰基丁烯酸酯的分子间环羰基化反应，以中等至良好的收率得到 2,3,3-三乙氧羰基-2,3-二氢-4(1H)-喹啉酮衍生物。该反应经历迈克尔加成和随后的羰基化反应。
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