Wei Huamian, Su Ling, Feng Yi, He Xiang, His Jenny, Liang Shu, Shao Yiming
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
AIDS Res Hum Retroviruses. 2013 Aug;29(8):1173-6. doi: 10.1089/aid.2013.0104. Epub 2013 May 21.
In recent years, the men who have sex with men (MSM) population has seen the fastest growing prevalence of HIV transmission in China. In addition, coinfection through sex and intravenous drug use is a major problem in HIV prevention and control. Recent studies have also revealed that three major viral strains (CRF07_BC, CRF01_AE, and subtype B) have been cocirculating among MSM in Sichuan, suggesting a high probability of generating new recombinants. This study reports a near full-length genome of a novel HIV-1 recombinant (MSM0720) between CRF07_BC and CRF01_AE. The analysis of MSM0720 shows that the genome is composed of at least 11 interlaced segments, including six CRF07_BC and five CRF01_AE segments, with CRF07_BC as the backbone; this is different from a previously identified CRF01_AE/07_BC recombinant strain in intravenous drug users from Jiangsu.
近年来，男男性行为者（MSM）人群已成为中国HIV传播率增长最快的群体。此外，通过性行为和静脉注射吸毒导致的合并感染是HIV防控工作中的一个主要问题。最近的研究还表明，三种主要病毒株（CRF07_BC、CRF01_AE和B亚型）在四川的男男性行为者中共同传播，这表明产生新的重组体的可能性很高。本研究报告了一种新型HIV-1重组体（MSM0720）在CRF07_BC和CRF01_AE之间的近全长基因组。对MSM0720的分析表明，该基因组由至少11个交错片段组成，包括6个CRF07_BC片段和5个CRF01_AE片段，以CRF07_BC为骨干；这与之前在江苏静脉注射吸毒者中鉴定出的CRF01_AE/07_BC重组毒株不同。
